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OXA-207, a novel OXA-24 variant with reduced catalytic efficiency against carbapenems in acinetobacter pittii from Spain

Abstract: A carbapenem-resistant Acinetobacter pittii strain carrying an OXA-24-like enzyme was isolated in northern Spain in 2008. Sequence analysis confirmed the presence of the novel blaOXA-207 gene flanked by the site-specific XerC/XerD-like recombination binding sites and showing a unique Gly222Val substitution compared to OXA-24. Cloning and kinetic analysis showed that OXA-207 presents a reduction in the catalytic efficiency against carbapenems and a noticeable increase for oxacillin.

 Autoría: Cayô R., Merino M., Del Castillo B.R., Cano M.E., Calvo J., Bou G., Martínez-Martínez L.,

 Fuente: Antimicrob Agents Chemother. 2014 , 58(8), 4944-4948

Editorial: American Society for Microbiology

 Año de publicación: 2014

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

 DOI: 10.1128/AAC.02633-13

ISSN: 0066-4804,1098-6596,1070-6283

Autoría

CAYÓ, RODRIGO

MERINO, MARIA

RUIZ DEL CASTILLO, BELEN

ELIECER CANO, MARÍA

CALVO, JORGE

BOU, GERMÁN

LUIS MARTINEZ MARTINEZ