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High-sensitivity troponin T: a potential safety predictive biomarker for discharge from the emergency department of patients with confirmed influenza

Abstract: The purpose of the study was to analyze the relationship between the high-sensitivity troponin T levels in patients with confirmed influenza virus infection and its severity determined by mortality during the care process. In addition, a high-sensitivity troponin T cut-off value was sought to allow us to a safe discharge from the emergency department. An analytical retrospective observational study was designed in which high-sensitivity troponin T is determined as an exposure factor, patients are followed until the resolution of the clinical picture, and the frequency of mortality is analyzed. We included patients ? 16 years old with confirmed influenza virus infection and determination of high-sensitivity troponin T. One hundred twenty-eight patients were included (96.9% survivors, 3.1% deceased). Mean and median blood levels of high-sensitivity troponin T of survivors were 26.2 ± 58.3 ng/L and 14.5 ng/L (IQR 16 ng/L), respectively, and were statistically different when compared with those of the deceased patients, 120.5 ± 170.1 ng/L and 40.5 ng/L (IQR 266.5 ng/L), respectively, p = 0.012. The Youden index using mortality as the reference method was 0.76, and the cut-off value associated with this index was 24 ng/L (sensitivity 100%, specificity 76%, NPV 100%, PPV 4%) with AUC of 88,8% (95% CI: 79.8?92.2%), p < 0.001. We conclude that high-sensitivity troponin T levels in confirmed virus influenza infection are a good predictor of mortality in our population, and this predictor is useful for safely discharging patients from the emergency department.

 Fuente: Journal of Personalized Medicine 2022, 12, 520

Editorial: Basel: MDPI AG

 Año de publicación: 2022

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jpm12040520

ISSN: 2075-4426

Autores/as

MANUEL ANTONIO TAZON VARELA

ORTIZ DE SALIDO-MENCHACA, JON ORTIZ

PEDRO MUÑOZ CACHO

IRIONDO-BERNABEU, ENARA

MARTOS-ALMAGRO, MARÍA JOSEFA

LAVÍN-LÓPEZ, EMMA

VEGA-ZUBIAUR, ANDER

ESCALONA-CANAL, EDGAR JOSÉ

ALCALDE-DÍEZ, IRATXE

GÓMEZ-VILDOSOLA, CARMEN

BELZUNEGUI-GÁRATE, AINHOA

ESPINOZA-CUBA, FABIOLA

LÓPEZ-CEJUELA, JOSÉ ANTONIO

GARCÍA-GARCÍA, ALBA

TORREJÓN-CERECEDA, ALEJANDRO

NISA-MARTÍNEZ, ELENA SABINA

MOREIRA NIETO, DIANA

HELLÍN-MERCADAL, CINTIA

GARCÍA-CABALLERO, ANDER