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The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

Abstract: The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the ?4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ?4 allele of the APOE gene.

 Autoría: Lambert J.C., Sleegers K., González-Pérez A., Ingelsson M., Beecham G.W., Hiltunen M., Combarros O., Bullido M.J., Brouwers N., Bettens K., Berr C., Pasquier F., Richard F., Dekosky S.T., Hannequin D., Haines J.L., Tognoni G., Fiévet N., Dartigues J.F., Tzourio C., Engelborghs S., Arosio B., Coto E., De Deyn P., Del Zompo M., Mateo I., Boada M., Antunez C., Lopez-Arrieta J., Epelbaum J., Schjeide B.M.M., Frank-Garcia A., Giedraitis

 Fuente: Journal of Alzheimer's Disease, 2010, 22(1), 247-255

 Editorial: IOS Press

 Año de publicación: 2010

 Nº de páginas: 9

 Tipo de publicación: Artículo de Revista

 DOI: 10.3233/JAD-2010-100933

 ISSN: 1387-2877,1875-8908

Autoría

LAMBERT, JEAN-CHARLES

SLEEGERS, KRISTEL

GONZÁLEZ-PÉREZ, ANTONIO

INGELSSON, MARTIN

BEECHAM, GARY W.

HILTUNEN, MIKKO

ONOFRE COMBARROS PASCUAL

BULLIDO, MARIA J.

BROUWERS, NATHALIE

BETTENS, KAROLIEN

BERR, CLAUDINE

PASQUIER, FLORENCE

RICHARD, FLORENCE

DEKOSKY, STEVEN T.

HANNEQUIN, DIDIER

HAINES, JONATHAN L.

TOGNONI, GLORIA

FIÉVET, NATHALIE

DARTIGUES, JEAN-FRANÇOIS

TZOURIO, CHRISTOPHE