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A standardised protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia

Abstract: The European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI) is a consortium established with the ambition to set up the largest European longitudinal trial-ready cohort of Spinocerebellar Ataxia Type 3/Machado-Joseph Disease (SCA3/MJD), the most common autosomal dominantly inherited ataxia worldwide. A major focus of ESMI has been the identification of SCA3/MJD biomarkers to enable future interventional studies. As biosample collection and processing variables significantly impact the outcomes of biomarkers studies, biosampling procedures standardisation was done previously to study visit initiation. Here, we describe the ESMI consensus biosampling protocol, developed within the scope of ESMI, that ultimately might be translated to other neurodegenerative disorders, particularly ataxias, being the first step to protocol harmonisation in the field

 Fuente: Neuropathology and applied neurobiology, 2023, 49(2), e12892

Editorial: Wiley

 Año de publicación: 2023

Nº de páginas: 14

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/nan.12892

ISSN: 0305-1846,1365-2990

Url de la publicación: https://doi.org/10.1111/nan.12892

Autoría

SANTANA, MAGDA M.

GASPAR, LAETITIA S.

PINTO, MARIA M.

SILVA, PATRICK

ADÃO, DIANA

PEREIRA, DINA

AFONSO RIBEIRO, JOANA

CUNHA, INÉS

HUEBENER-SCHMID, JEANNETTE

RAPOSO, MAFALDA

FERREIRA, ANA F.

FABER, JENNIFER

KUHS, SANDRA

GARCIA-MORENO, HECTOR

REETZ, KATHRIN

THIEME, ANDREAS

VAN DE WARRENBURG, BART P. C.

GIUNTI, PAOLA

RIESS, OLAF