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Radiation therapy for vulvar cancer: consensus guidelines of the GINECOR working group of the Spanish Society of Radiation Oncology. Part 1: clinical recommendations

Abstract: Purpose: The present consensus statement was developed by the GINECOR working group on behalf of the Spanish Society of Radiation Oncology (SEOR). Given the lack of prospective data on the management of vulvar carcinoma, this document provides an up-to-date review of radiotherapy treatment in vulvar cancer and a series of consensus-based recommendations from a group of experts. Methods: A two-round, online modified Delphi study was conducted to reach consensus treatment recommendations in three clinical settings: 1) adjuvant treatment, 2) locally-advanced vulvar cancer (LAVC), and 3) recurrent disease. After the first round, we comprehensively reviewed the available medical literature from peer-reviewed journals to assess and define the evidence-based treatment options. In the second round, participants were asked to indicate their level of agreement with the preliminary recommendations according to the GRADE (Grade of Recommendation, Assessment, Development, and Evaluation) criteria, as follows: strongly agree; agree; neither agree nor disagree; disagree; strongly disagree. Results: The main recommendations were as follows: 1) following surgical resection, adjuvant radiotherapy is recommended with the presence of adverse risk factors (primarily positive margins and lymph node involvement); 2) radiotherapy (with or without chemotherapy) should be considered in LAVC; and 3) in recurrent disease, radiotherapy should be individualised on a case-by-case basis. A high level of agreement over 80% was reached. Conclusions: In the absence of robust clinical data, these final recommendations may help to select the optimal radiotherapy approach for this relatively rare cancer.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Clinical and Translational Oncology, 2023, 25, 2153-2168 - (CORRIGENDUM), 2023, 25, 2153-2168

Editorial: Springer-Verlag Italia

 Año de publicación: 2023

Nº de páginas: 16

Tipo de publicación: Artículo de Revista

 DOI: 10.1007/s12094-023-03095-8

ISSN: 1699-048X,1699-3055

Url de la publicación: https://doi.org/10.1007/s12094-023-03095-8

Autoría

CÓRDOBA LAGO, SOFÍA

RODRÍGUEZ RODRÍGUEZ, ISABEL

RODRÍGUEZ VILLALBA, SILVIA

NAJJARI JAMAL, DINA

CELADA ÁLVAREZ, FRANCISCO

GARCÍA CABEZAS, SONIA

FUENTE ALONSO, CRISINA DE

COSUELO PANIAGUA, LUZ

MARTÍNEZ MONTESINOS, IRENE

VILLAFRANCA ITURRE, ELENA

BELINCHÓN OLMEDA, BELÉN

FARGA ALBIOL, DOLORES

PAOLA ANDREA NAVARRETE SOLANO

SÁNCHEZ BELDA, MARÍA