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 Detalle_Publicacion

MYC oncogene in myeloid neoplasias

Abstract: MYC is a transcription factor that regulates many critical genes for cell proliferation, differentiation, and biomass accumulation. MYC is one of the most prevalent oncogenes found to be altered in human cancer, being deregulated in about 50 % of tumors. Although MYC deregulation has been more frequently associated to lymphoma and lymphoblastic leukemia than to myeloid malignancies, a body of evidence has been gathered showing that MYC plays a relevant role in malignancies derived from the myeloid compartment. The myeloid leukemogenic activity of MYC has been demonstrated in different murine models. Not surprisingly, MYC has been found to be amplified or/and deregulated in the three major types of myeloid neoplasms: acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms, including chronic myeloid leukemia. Here, we review the recent literature describing the involvement of MYC in myeloid tumors.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Delgado M., Albajar M., Gomez-Casares M., Batlle A., León J.,

 Fuente: Clinical and Translational Oncology, 2013, 15(2), 87-94

Editorial: Springer-Verlag

 Fecha de publicación: 01/02/2013

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1007/s12094-012-0926-8

ISSN: 1699-048X,1699-3055

 Proyecto español: SAF11-23796

Url de la publicación: https://doi.org/10.1007/s12094-012-0926-8

Autoría

MARTA ALBAJAR MOLERA

GÓMEZ-CASARES, M. TERESA

MARIA ANA BATLLE LOPEZ