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Incidence and prognosis of colorectal cancer after heart transplantation: data from the spanish post-heart transplant tumor registry

Abstract: In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for ageat- diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Transplant international : official journal of the European Society for Organ Transplantation, 2023, 36, 11042

Editorial: Blackwell Publishing Ltd

 Año de publicación: 2023

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.3389/ti.2023.11042

ISSN: 0934-0874,1432-2277

Autores/as

SAGASTAGOITIA-FORNIE, MARTA

MORÁN-FERNÁNDEZ, LAURA

BLÁZQUEZ-BERMEJO, ZORBA

DÍAZ-MOLINA, BEATRIZ

GÓMEZ-BUENO, MANUEL

ALMENAR-BONET, LUIS

LÓPEZ-GRANADOS, AMADOR

MIRABET-PÉREZ, SONIA

GARCÍA-ROMERO, ELENA

SOBRINO-MÁRQUEZ, JOSE M.

RÁBAGO JUAN-ARACIL, GREGORIO

CASTEL-LAVILLA, MARIA ANGELS

BLASCO-PEIRO, TERESA

GARRIDO-BRAVO, IRIS

FUENTE-GALÁN, LUIS DE LA

MUÑIZ, JAVIER

CRESPO-LEIRO, MARÍA G.