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Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Abstract: Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300?10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Nature Genetics, 2013, 45(10), 1150-1159

Editorial: Nature Publishing Group

 Año de publicación: 2013

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/ng.2742

ISSN: 1061-4036,1546-1718

Url de la publicación: https://doi.org/10.1038/ng.2742

Autoría

RIPKE, STEPHAN

O'DUSHLAINE, COLM

CHAMBERT, KIMBERLY

MORAN, JENNIFER L.

KÄHLER, ANNA K.

AKTERIN, SUSANNE

BERGEN, SARAH E.

COLLINS, ANN L.

CROWLEY, JAMES J.

FROMER, MENACHEM

KIM, YUNJUNG

LEE, SANG HONG

MAGNUSSON, PATRIK K. E.

SANCHEZ, NICK

STAHL, ELI A.

WILLIAMS, STEPHANIE

WRAY, NAOMI R.

XIA, KAI

BENEDICTO CRESPO FACORRO

IGNACIO MATA PASTOR