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Effect of immunomodulatory therapies in patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia.

Abstract: Objective: To determine the effect of immunomodulatory therapies on the development of severe disease in hospitalized adults with laboratory-confirmed pandemic influenza A (H1N1) 2009 complicated by pneumonia. Methods: Observational, prospective cohort study at thirteen tertiary hospitals in Spain. The use of corticosteroids, macrolides and statins was recorded. The outcome of interest was severe disease, defined as the composite of intensive care unit admission or death after the first day of hospitalization. Results: Of the 197 patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia, 68 (34.5%) received some anti-inflammatory therapy since hospital admission (corticosteroids in 37, macrolides in 31 and statins in 12). Severe disease occurred in 29 (14.7%) patients. After adjustment for confounding factors, immunomodulatory therapies as a group were not associated with a lower risk for developing severe disease (odds ratio [OR] 0.64; 95% confidence interval [CI] 0.22?1.86). In a further a priori analysis, corticosteroids, macrolides and statins were included in a multivariate model. None of these therapies was found to be associated with a lower risk for developing severe disease. Conclusions: Immunomodulatory therapies use since hospital admission did not prevent the development of severe disease in adults with pandemic influenza A (H1N1) 2009 complicated by pneumonia.

 Fuente: Journal of Infection, 2011, 62(3), 193-199

 Editorial: Elsevier

 Año de publicación: 2011

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.jinf.2011.01.014

 ISSN: 0163-4453

 Url de la publicación: https://doi.org/10.1016/j.jinf.2011.01.014

Autoría

VIASUS, DIEGO

PAÑO PARDO, JOSÉ RAMÓN

CORDERO, ELISA

CAMPINS, ANRTONI

LOPEZ MEDRANO, FRANCISCO

VILLOSLADA, AROA

RODRÍGUEZ BAÑO, JESÚS

OTEO, JOSÉ ANTONIO

MARTÍNEZ MONTAUTI, JOAQUÍN

TORRE CISNEROS, JULIÁN

SEGURA, FERRÁN

CARRATALÁ, JORDI