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Community-acquired pneumonia during the first post-pandemic influenza season: a prospective, multicentre cohort study.

Abstract: Objectives: To determine the aetiology, clinical features and prognosis of CAP during the first post-pandemic influenza season. We also assessed the factors associated with severe disease and tested the ability of a scoring system for identifying influenza A (H1N1)pdm09-related pneumonia. Methods: Prospective cohort study carried out at 10 tertiary hospitals of Spain. All adults hospitalised with CAP from December 01, 2010 to March 31, 2011 were analysed. Results: A total of 747 adults with CAP required hospitalisation. The aetiology was determined in 315 (42.2%) patients, in whom 154 (21.9%) were due to bacteria, 125 (16.7%) were due to viruses and 36 (4.8%) were mixed (due to viruses and bacteria). The most frequently isolated bacteria were Streptococccus pneumoniae. Among patients with viral pneumonia, the most common organism identified were influenza A (H1N1)pdm09. Independent factors associated with severe disease were impaired consciousness, septic shock, tachypnea, hyponatremia, hypoxemia, influenza B, and influenza A (H1N1)pdm09. The scoring system evaluated did not differentiate reliably between patients with influenza A (H1N1)pdm09-related pneumonia and those with other aetiologies. Conclusions: The frequency of bacterial and viral pneumonia during the first post-pandemic influenza season was similar. The main identified virus was influenza A (H1N1)pdm09, which was associated with severe disease. Although certain presenting clinical features may allow recognition of influenza A (H1N1)pdm09-related pneumonia, it is difficult to express them in a reliable scoring system. © 2013 The British Infection Association.

 Fuente: Journal of Infection, 2013, 67(3), 185-193

 Editorial: Elsevier

 Año de publicación: 2013

 Nº de páginas: 9

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.jinf.2013.05.006

 ISSN: 0163-4453

 Proyecto español: REIPI RD12/0015

Autoría

VIASUS, DIEGO

MARINESCU, CARMEN

VILLOSLADA, AROA

CORDERO, ELISA

GÁLVEZ-ACEBAL, JUAN

GRACIA-AHUFINGER, IRENE

FERNÁNDEZ-NAVARRO, ANABEL

NIUBÓ, JORDI

ORTEGA, LUCÍA

MUÑEZ-RUBIO, ELENA

ROMERO-GÓMEZ, MARÍA P.

CARRATALÀ, JORDI