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Abstract: Introduction: As Hearing loss and dementia affect people with the same profile, several epidemiological studies have evaluated their relationship. However, the link between age-related hearing loss and Alzheimer's disease is still unclear. Methods: We selected subjects with no history of exposure to loud noises, blasts, head trauma with hearing loss, or sudden sensorineural hearing loss from a cohort intended to study preclinical phases of Alzheimer's disease. Participants are volunteers over 55 years without cognitive impairment. We correlated the results of an objective auditory evaluation with brain amyloid and p-tau181 levels and with the outcomes of a comprehensive neuropsychological assessment. Results: Fifty-five subjects at different stages of the Alzheimer's disease continuum were evaluated. There were no statistically significant correlations between amyloid-beta and p-tau levels and any of the objective auditory measures. A weak but significant correlation was found between amyloid-beta values and the Hearing Handicap Inventory for the Elderly. The neuropsychological domains more correlated to hearing loss were executive function and processing speed. Discussion: Age-related hearing loss is not linked to any pathological markers of Alzheimer's disease nor to neuropsychological domains typically affected in this disease. The Hearing Handicap Inventory for the Elderly has an important component of subjectivity and further studies are needed to explore its relationship with amyloid-beta levels.
Fuente: Neurological Sciences, 2024, 45, 1471-1480
Editorial: Springer Verlag
Año de publicación: 2023
Nº de páginas: 10
Tipo de publicación: Artículo de Revista
DOI: 10.1007/s10072-023-07143-7
ISSN: 1590-1874,1590-3478
Url de la publicación: https://doi.org/10.1007/s10072-023-07143-7
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MARTÍNEZ-DUBARBIE, FRANCISCO
DAVID LOBO DURO
MARIA ROLLAN MARTINEZ-HERRERA
SARA LOPEZ GARCIA
CARMEN LAGE MARTINEZ
MARTA FERNANDEZ MATARRUBIA
ANA POZUETA CANTUDO
GARCÍA-MARTÍNEZ, MARÍA
ANDREA CORRALES PARDO
MARIA PAZ BRAVO GONZALEZ
RAMON COBO DIAZ
CABIECES-JUNCAL, DANIEL
MARCOS LOPEZ HOYOS
JUAN IRURE VENTURA
PASCUAL JESUS SANCHEZ JUAN
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