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Age-related hearing loss is not linked to cerebrospinal fluid levels of beta-amyloid or p-tau181

Abstract: Introduction: As Hearing loss and dementia affect people with the same profile, several epidemiological studies have evaluated their relationship. However, the link between age-related hearing loss and Alzheimer's disease is still unclear. Methods: We selected subjects with no history of exposure to loud noises, blasts, head trauma with hearing loss, or sudden sensorineural hearing loss from a cohort intended to study preclinical phases of Alzheimer's disease. Participants are volunteers over 55 years without cognitive impairment. We correlated the results of an objective auditory evaluation with brain amyloid and p-tau181 levels and with the outcomes of a comprehensive neuropsychological assessment. Results: Fifty-five subjects at different stages of the Alzheimer's disease continuum were evaluated. There were no statistically significant correlations between amyloid-beta and p-tau levels and any of the objective auditory measures. A weak but significant correlation was found between amyloid-beta values and the Hearing Handicap Inventory for the Elderly. The neuropsychological domains more correlated to hearing loss were executive function and processing speed. Discussion: Age-related hearing loss is not linked to any pathological markers of Alzheimer's disease nor to neuropsychological domains typically affected in this disease. The Hearing Handicap Inventory for the Elderly has an important component of subjectivity and further studies are needed to explore its relationship with amyloid-beta levels.

 Fuente: Neurological Sciences, 2024, 45, 1471-1480

Editorial: Springer Verlag

 Año de publicación: 2023

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1007/s10072-023-07143-7

ISSN: 1590-1874,1590-3478

Url de la publicación: https://doi.org/10.1007/s10072-023-07143-7

Autoría

MARTÍNEZ-DUBARBIE, FRANCISCO

DAVID LOBO DURO

MARIA ROLLAN MARTINEZ-HERRERA

SARA LOPEZ GARCIA

CARMEN LAGE MARTINEZ

MARTA FERNANDEZ MATARRUBIA

ANA POZUETA CANTUDO

GARCÍA-MARTÍNEZ, MARÍA

ANDREA CORRALES PARDO

MARIA PAZ BRAVO GONZALEZ

RAMON COBO DIAZ

CABIECES-JUNCAL, DANIEL

JUAN IRURE VENTURA

PASCUAL SANCHEZ JUAN