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Abstract: Background and objective
Freezing of gait (FOG) is a disabling symptom more frequent in Parkinson?s disease (PD) patients with postural instability gait difficulty (PIGD) phenotype. The aim of this study was to determine the prevalence of self-reported FOG in a large group of PD patients as well as assess its relationship with functional dependency with regard to motor phenotype.
The data correspond to the baseline evaluation of the COPPADIS-2015 study. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the freezing of gait questionnaire (FOG-Q). Functional dependency was defined as a Schwab and England (S&E) ADL scale score less than 80%. PIGD and non-PIGD (tremor dominant + indeterminate) groups were considered regarding to motor phenotype.
Among the 689 PD patients (62.6?±?8.9 years old, 59.8% males), 240 reported FOG (34.8%), whereas 63 presented functional dependency (9.1%). A total of 22.1% of patients with FOG presented functional dependency vs. only 2.2% of those without FOG (p 0.0001). FOG was related to functional dependency (OR?=?3.470; 95%CI 1.411?8.530; p =?0.007) after adjustment to age, gender, disease duration, daily equivalent levodopa dose, comorbidity (number of non-antiparkinsonian drugs/day), motor status (UPDRS-III), PIGD phenotype, motor complications (UPDRS-IV), NMS burden (NMSS total score), cognition (PD-CRS), and mood (BDI-II). However, according to motor phenotype, FOG was related to functional dependency only in PIGD patients (OR?=?7.163; 95%CI 1.206?42.564; p =?0.030).
Self-reported FOG is associated with functional dependency in PIGD but not in non-PIGD motor phenotype patients.
Fuente: Neurological sciences 41, 2883-2892 (2020)
Editorial: Springer Verlag
Fecha de publicación: 01/04/2020
Nº de páginas: 10
Tipo de publicación: Artículo de Revista
Url de la publicación: https://doi.org/10.1007/s10072-020-04404-7
DEUS-FONTICOBA, TERES DE
SUÁREZ CASTRO, ESTER
ANEIROS DÍAZ, ÁNGEL M.
FEAL-PAINCEIRAS, MARÍA J.
PAZ-GONZÁLEZ, JOSE M.
ÁVILA-RIVERA, MARÍA A.
CATALÁN, MARÍA J
JON INFANTE CEBERIO