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Tubulo-interstitial inflammation increases the risk of graft loss after the recurrence of IgA nephropathy

Abstract: Background: Immunoglobulin A nephropathy (IgAN) is the most frequent recurrent disease in kidney transplant recipients and its recurrence contributes to reducing graft survival. Several variables at the time of recurrence have been associated with a higher risk of graft loss. The presence of clinical or subclinical inflammation has been associated with a higher risk of kidney graft loss, but it is not precisely known how it influences the outcome of patients with recurrent IgAN. Methods: We performed a multicentre retrospective study including kidney transplant recipients with biopsy-proven recurrence of IgAN in which Banff and Oxford classification scores were available. 'Tubulo-interstitial inflammation' (TII) was defined when 't' or 'i' were ?2. The main endpoint was progression to chronic kidney disease (CKD) stage 5 or to death censored-graft loss (CKD5/DCGL). Results: A total of 119 kidney transplant recipients with IgAN recurrence were included and 23 of them showed TII. Median follow-up was 102.9 months and 39 (32.8%) patients reached CKD5/DCGL. TII related to a higher risk of CKD5/DCGL (3 years 18.0% vs 45.3%, log-rank 7.588, P = .006). After multivariate analysis, TII remained related to the risk of CKD5/DCGL (HR 2.344, 95% CI 1.119?4.910, P = .024) independently of other histologic and clinical variables. Conclusions: In kidney transplant recipients with IgAN recurrence, TII contributes to increasing the risk of CKD5/DCGL independently of previously well-known variables. We suggest adding TII along with the Oxford classification to the clinical variables to identify recurrent IgAN patients at increased risk of graft loss who might benefit from intensified immunosuppression or specific IgAN therapies.

 Fuente: Clinical Kidney Journal, 2024, 17(1), 1-8

Editorial: Oxford University Press

 Año de publicación: 2024

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1093/ckj/sfad259

ISSN: 2048-8505,2048-8513

Url de la publicación: https://doi.org/10.1093/ckj/sfad259

Autoría

QUINTANA, LUIS F.

VÁZQUEZ-SÁNCHEZ, TERESA

SÁNCHEZ-FRUCTUOSO, ANA

BUXEDA, ANNA

GAVELA, EVA

CAZORLA, JUAN M.

CABELLO, SHEILA

BENEYTO, ISABEL

LÓPEZ-OLIVA, MARÍA O.

DIEKMANN, FRITZ

GÓMEZ-ORTEGA, JOSÉ M.

CALVA ROMERO, NATIVIDAD

PÉREZ-SÁEZ, MARÍA J.

SANCHO, ASUNCIÓN

MAZUECOS, AUXILIADORA

ESPÍ-REIG, JORDI

JIMÉNEZ, CARLOS

HERNÁNDEZ, DOMINGO