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Abstract: Objective - Oxidative stress is implicated in Parkinsons disease (PD) and Alzheimers disease (AD), and heme oxygenase-1 (HO-1) is a potent antioxidant overexpressed in PD substantia nigra and AD cerebral cortex and hippocampus, indicating a possible up-regulation of antioxidant defenses in both neurodegenerative diseases. The role of HO-1 in peripheral blood of PD and AD patients remains unresolved. Methods ? We measured serum HO-1 levels in 107 patients with PD, 105 patients with AD, 104 controls for PD and 120 controls for AD. Results - The median serum concentration of HO-1 was significantly higher in PD patients (2.04 ng ? ml) compared with that of PD controls (1.69 ng/ ml, P = 0.016), with PD patients predominating over controls in the upper tertile of serum HO-1 levels, whereas there was more PD controls than PD patients in the lower tertile (P = 0.006). Median serum levels of HO-1 did not differ significantly between AD patients and AD controls. Conclusion - The increase of serum HO-1 levels in PD patients could indicate a systemic antioxidant reaction related to a chronic oxidative stress state in PD brain.
Fuente: Acta Neurologica Scandinavica, 2010, 121(2), 136-138
Editorial: Wiley-Blackwell
Año de publicación: 2010
Nº de páginas: 3
Tipo de publicación: Artículo de Revista
DOI: 10.1111/j.1600-0404.2009.01261.x
ISSN: 0001-6314,1600-0404
Url de la publicación: https://doi.org/10.1111/j.1600-0404.2009.01261.x
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JOSE IGNACIO MATEO FERNANDEZ
JON INFANTE CEBERIO
PASCUAL SANCHEZ JUAN
GARCÍA-GOROSTIAGA, INÉS
ELOY MANUEL RODRIGUEZ RODRIGUEZ
JOSE LUIS VAZQUEZ HIGUERA
JOSE ANGEL BERCIANO BLANCO
ONOFRE COMBARROS PASCUAL
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