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Interleukin-9 in stable liver transplant recipients.

Abstract: Introduction: Interleukin-9 (IL-9) has recently been described to be involved in the maintenance of a tolerant environment, but there is no evidence of its role in human liver transplantation. The aim of our study was to measure the serum levels of IL-9 in stable liver transplant recipients and examine their influence on immunosuppressant load. Methods: Serum IL-9 levels were determined in 34 healthy subjects and 30 stable liver transplant recipients who were free of rejection episodes for at least 8 years. The results were analyzed according to the blood levels of calcineurin inhibitors (CNIs) at the time of the study: 13 patients showed high concentrations of either cyclosporine or tacrolimus (high CNI: cyclosporine > 80 ng/mL or tacrolimus > 5 ng/mL) and another 17 patients showed low CNI levels. Results: The concentrations of IL-9 were significantly higher among liver transplant recipients compared with healthy subjects. In addition, patients with low CNI blood levels showed higher serum levels of IL-9, an effect that was greater with tacrolimus, albeit not significantly. Conclusions: These preliminary results indicated that increased serum IL-9 concentrations accompanied a lower immunosuppressive load. It remains to be established whether this relates to induction of tolerance in liver transplantation.

 Fuente: Transplantation Proceedings, 2012, 44(6), 1536-1538

 Editorial: Elsevier

 Año de publicación: 2012

 Nº de páginas: 3

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.transproceed.2012.05.014

 ISSN: 0041-1345,1873-2623

 Url de la publicación: https://doi.org/10.1016/j.transproceed.2012.05.014

Autoría

FÁBREGA, EMILIO

DAVID SAN SEGUNDO ARRIBAS

FERNANDO CASAFONT MORENCOS

MORALEJA, IRENE

SAMPEDRO, BLANCA

FERNANDO PONS ROMERO