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Abstract: We evaluated the MYD88 L265P mutation in Waldenström?s macroglobulinemia (WM) and B-cell lymphoproliferative disorders by specific polymerase chain reaction (PCR) (sensitivity ?10?3). No mutation was seen in normal donors, while it was present in 101/117 (86%) WM patients, 27/31 (87%) IgM monoclonal gammapathies of uncertain significance (MGUS), 3/14 (21%) splenic marginal zone lymphomas and 9/48 (19%) non-germinal center (GC) diffuse large B-cell lymphomas (DLBCLs). The mutation was absent in all 28 GC-DLBCLs, 13 DLBCLs not subclassified, 35 hairy cell leukemias, 39 chronic lymphocytic leukemias (16 with M-component), 25 IgA or IgG-MGUS, 24 multiple myeloma (3 with an IgM isotype), 6 amyloidosis, 9 lymphoplasmacytic lymphomas and 1 IgM-related neuropathy. Among WM and IgM-MGUS, MYD88 L265P mutation was associated with some differences in clinical and biological characteristics, although usually minor; wild-type MYD88 cases had smaller M-component (1.77 vs 2.72?g/dl, P=0.022), more lymphocytosis (24 vs 5%, P=0.006), higher lactate dehydrogenase level (371 vs 265 UI/L, P=0.002), atypical immunophenotype (CD23?CD27++FMC7++), less Immunoglobulin Heavy Chain Variable gene (IGHV) somatic hypermutation (57 vs 97%, P=0.012) and less IGHV3?23 gene selection (9 vs 27%, P=0.014). These small differences did not lead to different time to first therapy, response to treatment or progression-free or overall survival.
Fuente: Leukemia, 2013, 27(8), 1722-1728
Editorial: Nature Publishing Group
Año de publicación: 2013
Tipo de publicación: Artículo de Revista
DOI: 10.1038/leu.2013.62
ISSN: 0887-6924,1476-5551
Leer publicación
JIMÉNEZ, CARMEN
SEBASTIÁN, ELENA
CHILLÓN, MARÍA CARMEN
GIRALDO, PILAR
MARIANO HERNÁNDEZ, J.
ESCALANTE, FERNANDO
GONZÁLEZ-LÓPEZ, TOMÁS JOSÉ
AGUILERA, CARMEN
COCA, ALFONSO G. DE
MURILLO, ILDA
ALCOCEBA, MIGUEL
CORRAL, ROCÍO
ENRIQUE MARIA OCIO SAN MIGUEL
BALANZATEGUI, ANA
MARÍN, LUIS ALBERTO
PAIVA, BRUNO
GUTIÉRREZ, NORMA C.
GONZÁLEZ, MARCOS E.
SARASQUETE, MARÍA EUGENIA
SAN MIGUEL, JESÚS F.
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