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Carbon nanotubes gathered onto silica particles lose their biomimetic properties with the cytoskeleton becoming biocompatible

Abstract: Carbon nanotubes (CNTs) are likely to transform the therapeutic and diagnostic fields in biomedicine during the coming years. However, the fragmented vision of their side effects and toxicity in humans has proscribed their use as nanomedicines. Most studies agree that biocompatibility depends on the state of aggregation/dispersion of CNTs under physiological conditions, but conclusions are confusing so far. This study designs an experimental setup to investigate the cytotoxic effect of individualized multiwalled CNTs compared to that of identical nanotubes assembled on submicrometric structures. Our results demonstrate how CNT cytotoxicity is directly dependent on the nanotube dispersion at a given dosage. When CNTs are gathered onto silica templates, they do not interfere with cell proliferation or survival becoming highly compatible. These results support the hypothesis that CNT cytotoxicity is due to the biomimetics of these nanomaterials with the intracellular nanofilaments. These findings provide major clues for the development of innocuous CNT-containing nanodevices and nanomedicines.

 Autoría: González-Domínguez E., Iturrioz-Rodríguez N., Padín-González E., Villegas J., García-Hevia L., Pérez-Lorenzo M., Parak W.J., Correa-Duarte M.A., Fanarraga M.L.,

 Fuente: International Journal of Nanomedicine, 2017, 12, 6317-6328

 Editorial: Dove Medical Press

 Año de publicación: 2017

 Nº de páginas: 12

 Tipo de publicación: Artículo de Revista

 DOI: 10.2147/IJN.S141794

 ISSN: 1178-2013,1176-9114

 Url de la publicación: https://doi.org/10.2147/IJN.S141794

Autoría

GONZÁLEZ DOMÍNGUEZ, ELENA

NEREA ITURRIOZ RODRIGUEZ

ESPERANZA PADÍN GONZÁLEZ

PÉREZ LORENZO, MOISÉS

PARAK, WOLFGANG J.

CORREA DUARTE, MIGUEL A.