Abstract: Patients with Down syndrome have a number of risk factors that theoretically could predispose them toosteoporosis, such as early ageing, development disorders, reduced physical activity, limited sun expo-sure, frequent comorbidities and use of drug therapies which could affect bone metabolism. In addition,the bone mass of these people may be affected by their anthropometric and body composition pecu-liarities. In general terms, studies in adults with Down syndrome reported that these people have lowerareal bone mineral density (g/cm2) than the general population. However, most of them have not takenthe smaller bone size of people with Down syndrome into account. In fact, when body mineral densityis adjusted by bone size and we obtain volumetric body mineral density (g/cm3), the difference betweenboth populations disappears. On the other hand, although people with Down syndrome have risk factorof hypovitaminosis D, the results of studies regarding 25(OH)D in this population are not clear. Likewise,the studies about biochemical bone markers or the prevalence of fractures are not conclusive.

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