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Abstract: Objectives: To determine cardiovascular (CV) mortality and incidence of the first CV event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD) after 5 years of follow-up. Methods: This is an analysis of the CARdiovascular in rheMAatology (CARMA) study after 5 years of follow-up. It includes patients with RA (n = 775), AS (n = 738) and PsA (n = 721), and individuals without CIRD (n = 677) attending outpatient rheumatology clinics from 67 public hospitals in Spain. Descriptive analyses were performed for the CV mortality at 5 years. The Systematic COronary Risk Evaluation (SCORE) function at 5 years was calculated to determine the expected risk of CV mortality. Poisson models were used to estimate the incidence rates of the first CVE. Hazard ratios of the risk factors involved in the development of the first CVE were evaluated using the Weibull proportional hazard model. Results: Overall, 2382 subjects completed the follow-up visit at 5 years. Fifteen patients died due to CVE. CV deaths observed in the CIRD cohort were lower than that predicted by SCORE risk charts. The highest incidence rate of CVE [7.39 cases per 1000 person-years (95% CI 4.63, 11.18)] was found in PsA patients. However, after adjusting for age, sex and CV risk factors, AS was the inflammatory disease more commonly associated with CVE at 5 years [hazard ratio 4.60 (P =0.02)], compared with those without CIRD. Conclusions: Cardiovascular mortality in patients with CIRD at 5 years of follow-up is lower than estimated. Patients with AS have a higher risk of developing a first CVE after 5 years of follow-up.
Fuente: Rheumatology (Oxford). 2021 Jun 18;60(6):2906-2915
Editorial: Oxford University Press
Año de publicación: 2021
Nº de páginas: 10
Tipo de publicación: Artículo de Revista
DOI: 10.1093/rheumatology/keaa737
ISSN: 1462-0324,1462-0332
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MARTÍN MARTÍNEZ, MARÍA A
CASTAÑEDA, SANTOS
SÁNCHEZ ALONSO, FERNANDO
GARCÍA GÓMEZ, CARMEN
GONZÁLEZ JUANATEY, CARLOS
SÁNCHEZ CUESTA, JESÚS T.
BELMONTE LÓPEZ, MARÍA A
TORNERO MOLINA, JESÚS
SANTOS REY, JOSÉ
SÁNCHEZ GONZÁLEZ, CARMEN O.
QUESADA, ESTEFANÍA
MORENO GIL, MARÍA P.
COBO IBAÑEZ, TATIANA
PINDO TANSDE, JOSÉ A.
BABÍO HERRÁEZ, JESÚS
BONILLA, GEMA
JUAN MAS, ANTONIO
MANERO RUIZ, FRANCISCO J.
ROMERA BAURÉS, MONTSERRAT
BACHILLER CORRAL, JAVIER
CHAMIZO CARMONA, EUGENIO
URIARTE ECENARRO, MIREM
BARBADILLO, CARMEN
FERNÁNDEZ CARBALLIDO, CRISTINA
AURRECOECHEA, ELENA
MOLLËR PARRERA, INGRID
FRANCISCO JAVIER LLORCA DIAZ
MIGUEL ANGEL GONZALEZ-GAY MANTECON
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