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Cardiovascular mortality and cardiovascular event rates in patients with inflammatory rheumatic diseases in the CARdiovascular in rheuMAtology (CARMA) prospective study-results at 5 years of follow-up

Abstract: Objectives: To determine cardiovascular (CV) mortality and incidence of the first CV event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD) after 5 years of follow-up. Methods: This is an analysis of the CARdiovascular in rheMAatology (CARMA) study after 5 years of follow-up. It includes patients with RA (n = 775), AS (n = 738) and PsA (n = 721), and individuals without CIRD (n = 677) attending outpatient rheumatology clinics from 67 public hospitals in Spain. Descriptive analyses were performed for the CV mortality at 5 years. The Systematic COronary Risk Evaluation (SCORE) function at 5 years was calculated to determine the expected risk of CV mortality. Poisson models were used to estimate the incidence rates of the first CVE. Hazard ratios of the risk factors involved in the development of the first CVE were evaluated using the Weibull proportional hazard model. Results: Overall, 2382 subjects completed the follow-up visit at 5 years. Fifteen patients died due to CVE. CV deaths observed in the CIRD cohort were lower than that predicted by SCORE risk charts. The highest incidence rate of CVE [7.39 cases per 1000 person-years (95% CI 4.63, 11.18)] was found in PsA patients. However, after adjusting for age, sex and CV risk factors, AS was the inflammatory disease more commonly associated with CVE at 5 years [hazard ratio 4.60 (P =0.02)], compared with those without CIRD. Conclusions: Cardiovascular mortality in patients with CIRD at 5 years of follow-up is lower than estimated. Patients with AS have a higher risk of developing a first CVE after 5 years of follow-up.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Rheumatology (Oxford). 2021 Jun 18;60(6):2906-2915

Editorial: Oxford University Press

 Año de publicación: 2021

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1093/rheumatology/keaa737

ISSN: 1462-0324,1462-0332

Autores/as

MARTÍN MARTÍNEZ, MARÍA A

CASTAÑEDA, SANTOS

SÁNCHEZ ALONSO, FERNANDO

GARCÍA GÓMEZ, CARMEN

GONZÁLEZ JUANATEY, CARLOS

SÁNCHEZ CUESTA, JESÚS T.

BELMONTE LÓPEZ, MARÍA A

TORNERO MOLINA, JESÚS

SANTOS REY, JOSÉ

SÁNCHEZ GONZÁLEZ, CARMEN O.

QUESADA, ESTEFANÍA

MORENO GIL, MARÍA P.

COBO IBAÑEZ, TATIANA

PINDO TANSDE, JOSÉ A.

BABÍO HERRÁEZ, JESÚS

BONILLA, GEMA

JUAN MAS, ANTONIO

MANERO RUIZ, FRANCISCO J.

ROMERA BAURÉS, MONTSERRAT

BACHILLER CORRAL, JAVIER

CHAMIZO CARMONA, EUGENIO

URIARTE ECENARRO, MIREM

BARBADILLO, CARMEN

FERNÁNDEZ CARBALLIDO, CRISTINA

AURRECOECHEA, ELENA

MOLLËR PARRERA, INGRID