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New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy.


Abstract: Alzheimer's disease (AD) is characterized by the presence of two aberrant structures: namely senile plaques, composed of amyloid-? peptide (A?), and neurofibrillary tangles, composed of tau protein. In this regard, A? and tau protein have been widely studied in research efforts aiming to find a therapy for AD. A? and tau pathologies do not always overlap. The precursor of A? is expressed in peripheral tissues and in the central nervous system (CNS), whereas tau is mainly a neuronal protein. Since AD is a disease of the CNS, it has been proposed that A? may initiate the disease process, with tau being the executor. In this review, we will focus on future studies of tau pathology, although we will comment on new beginnings for AD, as other molecules other than A? and tau may be involved in the onset of dementia.

 Fuente: J Alzheimers Dis. 2018;64(s1):S529-S534

Editorial: IOS Press

 Año de publicación: 2018

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

DOI: 10.3233/JAD-179916

ISSN: 1387-2877,1875-8908

Url de la publicación: https://dx.doi.org/10.3233/JAD-179916

Autores/as

HERNÁNDEZ, FÉLIX
LLORENS MARTÍN, MARÍA
BOLÓS, MARTA
PÉREZ, MAR
CUADROS, RAQUEL
PALLAS BAZARRA, NOEMÍ
ÁVILA, JESÚS