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 Detalle_Publicacion

Effect of Cold Ischemia Time on Kidney Graft Function and Survival: Differences Between Paired Kidney Transplants From the Same Donor

Abstract: Introduction: Kidney transplantation procedures commonly result in a cold ischemia time (CIT) gap when both kidney grafts are implanted in the same center. Owing to logistics, the procedure is usually consecutive, first accomplishing one surgery and then the other. CIT constitutes an independent risk factor for the development of delayed graft function (DGF) in kidney transplants. The effect that CIT exerts on graft and patient survival is still unclear. This study evaluates the relation of CIT and transplant outcomes by comparing paired kidney transplants in terms of survival and graft function. Methods: We accomplished a retrospective analysis of 402 kidney transplants performed in our center between 2000 and 2017. We selected all transplants where both organs from the same donor were implanted at our hospital, establishing 2 study groups (group 1: first graft implanted and group 2: second graft implanted) to compare by paired data statistical methods. Results: We found an increase in the incidence of DGF in group 2 (42% vs 28.8%; P < .05). Group 2 had significantly worse graft function on day 5 posttransplant (4.7 ± 2.88 vs 3.86 ± 2.8 mg/dL of serum creatinine; P < .05). No significant differences in graft function were found on days 30 and 90 posttransplant. We didn't find any difference in graft survival between both groups. Length of hospitalization stay (17.6 days [± 13] vs 21.6 days [± 17]) and hemodialysis sessions (mean of 2.8 [± 2] vs 3.6 [± 2.2]) were higher in group 2. Conclusion: CIT acts as an independent risk factor for the development of DGF in kidney transplantation. CIT had no isolated effect on graft survival.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Transplant Proc . 2019 Mar;51(2):321-323

Editorial: Elsevier

 Año de publicación: 2019

Nº de páginas: 3

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.transproceed.2018.10.012

ISSN: 0041-1345,1873-2623

Url de la publicación: https://doi.org/10.1016/j.transproceed.2018.10.012

Autores/as

PÉREZ-CANGA, J.L.

MARTÍN PENAGOS, L.

BALLESTERO DIEGO, R.

VALERO SAN CECILIO, R.

BELMAR VEGA, L.

SERRANO SOTO, M.

RUIZ MARTÍNEZ, L.

LOPEZ DEL MORAL CUESTA, C.

JUAN CARLOS RUIZ SAN MILLAN