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Abstract: Flow cytometry (FCM) is more sensitive than conventional cytology for detection of occult leptomeningeal lymphoma; however, some FCM-negative patients show central nervous system (CNS) recurrence. Here, we evaluated the cerebrospinal fluid (CSF) levels of 13 B-cell?associated markers and their contribution to the diagnosis of CNS lymphoma in 91 diffuse large B-cell lymphomas (DLBCL) and 22 Burkitt lymphomas (BLs). From all markers tested, CD19 was the most informative. Thus, higher soluble CD19 (sCD19) levels were associated with a greater frequency of neurological symptoms in DLBCL and BL and with parenchymal CNS lymphoma in DLBCL; sCD19 emerged as a powerful predictor of event-free and overall survival in DLBCL and BL, particularly when combined with FCM detection of CNS disease. These results support the utility of combined FCM detection of lymphoma cells and assessment of sCD19 levels in CSF, for more accurate identification of CNS disease in DLBCL and BL patients.
Fuente: Blood, 2014, 123(12), 1864-1869
Editorial: American Society of Hematology
Año de publicación: 2014
Nº de páginas: 9
Tipo de publicación: Artículo de Revista
ISSN: 0006-4971,1528-0020
MUÑIZ, CARMEN
MARTÍN-MARTÍN, LOURDES
LÓPEZ, ANTONIO
SÁNCHEZ-GONZÁLEZ, BLANCA
SALAR, ANTONIO
ALMEIDA, JULIA
SANCHO, JUAN-MANUEL
RIBERA, JOSÉ MARÍA
HERAS, CECILIA
PEÑALVER, FRANCISCO JAVIER
GÓMEZ, MARTA
GONZÁLEZ-BARCA, EVA
ALONSO, NATALIA
NAVARRO, BELÉN
OLAVE, TERESA
SALA, FRANCISCO
EULOGIO CONDE GARCIA
MÁRQUEZ, JOSÉ ANTONIO
CABEZUDO, ELENA
CLADERA, ANTONIA
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