Estamos realizando la búsqueda. Por favor, espere...
1583
37
170
29013
4402
2599
347
386
Abstract: The clinical value of multiparameter flow cytometry (MFC) immunophenotyping in primary or light chain amyloidosis (AL) remains unknown. We studied 44 consecutive bone marrow samples from newly diagnosed patients with amyloidosis; 35 patients with AL and 9 with other forms of amyloidosis. Monoclonal plasma cells (PCs) were identifiable by MFC immunophenotyping in 34 of 35 (97%) patients with AL, whereas it was absent from all but 1 of the 9 (11%) patients with other forms of amyloidosis. Quantification of bone marrow plasma cells (BMPCs) by MFC immunophenotyping was a significant prognostic factor for overall survival (OS) (? 1% vs > 1% BMPC cutoff; 2-year OS rates of 90% vs 44%, P = .02). Moreover, detecting persistent normal PCs at diagnosis identifies a subgroup of patients with AL with prolonged OS (> 5% vs ? 5% normal PC within all BMPC cutoff, 2-year rates of 88% vs 37%, P = .01). MFC immunophenotyping could be clinically useful for the demonstration of PC clonality in AL and for the prognostication of patients with AL.
Fuente: Blood, 2011, 117(13), 3613-3616
Editorial: American Society of Hematology
Año de publicación: 2011
Tipo de publicación: Artículo de Revista
DOI: 10.1182/blood-2010-12-324665
ISSN: 0006-4971,1528-0020
Url de la publicación: https://doi.org/10.1182/blood-2010-12-324665
Leer publicación
PAIVA, BRUNO
VÍDRIALES, MARÍA-BELÉN
PÉREZ, JOSÉ J.
LÓPEZ-BERGES, MARÍA-CONSUELO
GARCÍA-SANZ, RAMÓN
ENRIQUE MARIA OCIO SAN MIGUEL
DE LAS HERAS, NATALIA
CUELLO, REBECA
GARCÍA DE COCA, ALFONSO
PARDAL, EMILIA
ALONSO, JOSÉ
SIERRA, MAGDALENA
BÁREZ, ABELARDO
HERNÁNDEZ, JOSÉ
SUÁREZ, LISSBETT
GALENDE, JOSEFINA
MATEOS, MARÍA-VICTORIA
SAN MIGUEL, JESÚS F.
Volver