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Abstract: Solitary plasmacytoma represents a heterogeneous group of patients; approximately half develop multiple myeloma (MM) in 2 or 3 years, whereas others remain disease-free at 10 years. By definition, these patients do not have morphologic bone marrow (BM) plasma cell (PC) infiltration. Here, we investigated whether sensitive BM evaluation of patients with solitary bone plasmacytoma (SBP; n = 35) and extramedullary plasmacytoma (EMP; n = 29) through multiparameter flow cytometry (MFC) would unravel the presence of clonal PCs in otherwise disease-free BM, and whether BM clonality predicted higher risk of progression. BM clonal PCs were detected in 17 of 35 SBP (49%) and 11 of 29 EMP (38%) patients. Seventy-one percent of flow-positive vs only 8% of flow-negative SBP patients evolved to MM (median time to progression of 26 months vs not reached; hazard ratio, 17.4; P < .001). No significant differences were observed among EMP cases. Our results highlight the importance of MFC for sensitive BM evaluation of SBP patients, to predict risk of developing treatment-requiring MM and to plan disease monitoring.
Fuente: Blood, 2014, 124(8), 1300-1303
Editorial: American Society of Hematology
Año de publicación: 2014
Nº de páginas: 4
Tipo de publicación: Artículo de Revista
DOI: 10.1182/blood-2014-04-567909
ISSN: 0006-4971,1528-0020
Url de la publicación: https://doi.org/10.1182/blood-2014-04-567909
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PAIVA, BRUNO
CHANDIA, MAURICIO
VIDRIALES, MARIA-BELEN
COLADO, ENRIQUE
CABALLERO-VELÁZQUEZ, TERESA
ESCALANTE, FERNANDO
GARCIA DE COCA, ALFONSO
MONTES, MARIA-CARMEN
GARCIA-SANZ, RAMON
ENRIQUE MARIA OCIO SAN MIGUEL
OCIO, ENRIQUE M.
MATEOS, MARIA-VICTORIA
SAN MIGUEL, JESUS F.
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