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Abstract: Backkgroun: Schizophrenia is a chronic brain disorder associated with structural brain abnormalities already present at the onset of the illness. Whether these brain abnormalities might progress over time is still under debate.
Method: The aim of this study was to investigate likely progressive brain volume changes in schizophrenia during the first 3 years after initiating antipsychotic treatment. The study included 109 patients with a schizophrenia spectrum disorder and a control group of 76 healthy subjects. Subjects received detailed clinical and cognitive assessment and structural magnetic resonance imaging (MRI) at regular time points during a 3-year follow-up period. The effects of brain changes on cognitive and clinical variables were examined along with the impact of potential confounding factors.
Results: Overall, patients and healthy controls exhibited a similar pattern of brain volume changes. However, patients showed a significant lower progressive decrease in the volume of the caudate nucleus than control subjects (F 1,307.2 = 2.12, p = 0.035), with healthy subjects showing a greater reduction than patients during the follow-up period. Clinical and cognitive outcomes were not associated with progressive brain volume changes during the early years of the illness.
Conclusions: Brain volume abnormalities that have been consistently observed at the onset of non-affective psychosis may not inevitably progress, at least over the first years of the illness. Taking together with clinical and cognitive longitudinal data, our findings, showing a lack of brain deterioration in a substantial number of individuals, suggest a less pessimistic and more reassuring perception of the illness.
Fuente: Psychological Medicine, 2014, 44(8), 1591-1604
Editorial: Cambridge University Press
Año de publicación: 2014
Nº de páginas: 13
Tipo de publicación: Artículo de Revista
Url de la publicación: https://doi.org/10.1017/S0033291713002365
ROBERTO ROIZ SANTIAÑEZ
MARIA ROSA AYESA ARRIOLA
DIANA TORDESILLAS GUTIERREZ
ORTÍZ GARCÍA DE LA FOZ, VICTOR
ROCIO PEREZ IGLESIAS
ANGEL PAZOS CARRO
BENEDICTO CRESPO FACORRO