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Three-year longitudinal population-based volumetric MRI study in first-episode schizophrenia spectrum patients

Abstract: Backkgroun: Schizophrenia is a chronic brain disorder associated with structural brain abnormalities already present at the onset of the illness. Whether these brain abnormalities might progress over time is still under debate. Method: The aim of this study was to investigate likely progressive brain volume changes in schizophrenia during the first 3 years after initiating antipsychotic treatment. The study included 109 patients with a schizophrenia spectrum disorder and a control group of 76 healthy subjects. Subjects received detailed clinical and cognitive assessment and structural magnetic resonance imaging (MRI) at regular time points during a 3-year follow-up period. The effects of brain changes on cognitive and clinical variables were examined along with the impact of potential confounding factors. Results: Overall, patients and healthy controls exhibited a similar pattern of brain volume changes. However, patients showed a significant lower progressive decrease in the volume of the caudate nucleus than control subjects (F 1,307.2 = 2.12, p = 0.035), with healthy subjects showing a greater reduction than patients during the follow-up period. Clinical and cognitive outcomes were not associated with progressive brain volume changes during the early years of the illness. Conclusions: Brain volume abnormalities that have been consistently observed at the onset of non-affective psychosis may not inevitably progress, at least over the first years of the illness. Taking together with clinical and cognitive longitudinal data, our findings, showing a lack of brain deterioration in a substantial number of individuals, suggest a less pessimistic and more reassuring perception of the illness.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Psychological Medicine, 2014, 44(8), 1591-1604

Editorial: Cambridge University Press

 Año de publicación: 2014

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.1017/S0033291713002365

ISSN: 0033-2917,1469-8978

Url de la publicación: https://doi.org/10.1017/S0033291713002365

Autores/as

ROBERTO ROIZ SANTIAÑEZ

MARIA ROSA AYESA ARRIOLA

DIANA TORDESILLAS GUTIERREZ

ORTÍZ GARCÍA DE LA FOZ, VICTOR

ROCIO PEREZ IGLESIAS

SÁNCHEZ, E

BENEDICTO CRESPO FACORRO