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Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis

Abstract: Background Neuroanatomical abnormalities in first-episode psychosis (FEP) tend to be subtle and widespread. The vast majority of previous studies have used small samples, and therefore may have been underpowered. In addition, most studies have examined participants at a single research site, and therefore the results may be specific to the local sample investigated. Consequently, the findings reported in the existing literature are highly heterogeneous. This study aimed to overcome these issues by testing for neuroanatomical abnormalities in individuals with FEP that are expressed consistently across several independent samples. Methods Structural Magnetic Resonance Imaging data were acquired from a total of 572 FEP and 502 age and gender comparable healthy controls at five sites. Voxel-based morphometry was used to investigate differences in grey matter volume (GMV) between the two groups. Statistical inferences were made at p < 0.05 after family-wise error correction for multiple comparisons. Results FEP showed a widespread pattern of decreased GMV in fronto-temporal, insular and occipital regions bilaterally; these decreases were not dependent on anti-psychotic medication. The region with the most pronounced decrease-gyrus rectus-was negatively correlated with the severity of positive and negative symptoms. Conclusions This study identified a consistent pattern of fronto-temporal, insular and occipital abnormalities in five independent FEP samples; furthermore, the extent of these alterations is dependent on the severity of symptoms and duration of illness. This provides evidence for reliable neuroanatomical alternations in FEP, expressed above and beyond site-related differences in anti-psychotic medication, scanning parameters and recruitment criteria.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Psychological Medicine, 2021, 51(2), 340-350

Editorial: Cambridge University Press

 Año de publicación: 2021

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.1017/S0033291719003568

ISSN: 0033-2917,1469-8978

Url de la publicación: https://doi.org/10.1017/S0033291719003568

Autoría

VIEIRA, SANDRA

GONG, QIYONG

SCARPAZZA, CRISTINA

LUI, SU

HUANG, XIAOQI

BENEDICTO CRESPO FACORRO

DIANA TORDESILLAS GUTIERREZ

VICTOR ORTIZ GARCIA DE LA FOZ

MARIA ESTHER SETIEN SUERO

SCHEEPERS, FLOOR

HAREN, NEELTJE E. M. VAN

KAHN, RENÉ

REIS MARQUES, TIAGO

CIUFOLINI, SIMONE

DI FORTI, MARTA

MURRAY, ROBIN M.

DAVID, ANTHONY

DAZZAN, PAOLA

MCGUIRE, PHILIP

MECHELLI, ANDREA