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 Detalle_Publicacion

Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: a cross-sectional study

Abstract: Background: MOTS-c and Romo1 are mitochondrial peptides that are modulated by oxidative stress. No previous studies have explored circulating levels of MOTS-c in patients with chronic obstructive pulmonary disease (COPD). Methods: We enrolled 142 patients with stable COPD and 47 smokers with normal lung function in an observational cross-sectional study. We assessed serum levels of both MOTS-c and Romo1 and associated these findings with clinical characteristics of COPD. Results: Compared with smokers with normal lung function, patients with COPD had lower levels of MOTS-c (p = 0.02) and higher levels of Romo1 (p = 0.01). A multivariate logistic regression analysis revealed that above-median MOTS-c levels were positively associated with Romo1 levels (OR 1.075, 95% CI 1.005?1.150, p = 0.036), but no association was found with other COPD characteristics. Below-median levels of circulating MOTS-c were associated with oxygen desaturation (OR 3.25 95% CI 1.456?8.522, p = 0.005) and walking <350 meters (OR 3.246 95% CI 1.229?8.577, p = 0.018) in six-minute walk test. Above-median levels of Romo1 were positively associated with current smoking (OR 2.756, 95% CI 1.133?6.704, p = 0.025) and negatively associated with baseline oxygen saturation (OR 0.776 95% CI 0.641?0.939, p = 0.009). Conclusions: Reduced levels of circulating MOTS-c and increased levels of Romo1 were detected in patients diagnosed with COPD. Low levels of MOTS-c were associated with oxygen desaturation and poorer exercise capacity using 6 min walk test. Romo1 was associated with current smoking and baseline oxygen saturation.

 Fuente: Frontiers in Medicine, 2023, 10, 1100211

Editorial: Frontiers Media S.A.

 Año de publicación: 2023

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.3389/fmed.2023.1100211

ISSN: 2296-858X

Proyecto español: PT17/0015/0019

Url de la publicación: https://doi.org/10.3389/fmed.2023.1100211

Autores/as

MARTÍN-AUDERA, PAULA

AGÜERO, JUAN

BERNARDO ALIO LAVIN GOMEZ

ARMANDO RAUL GUERRA RUIZ

BOUCLE, DAYMARA

DIEGO JOSE FERRER PARGADA

BERJA, ANA

MARTÍN, FERNANDO

CASANOVA, CIRO