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Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections

Abstract: Introduction: Whole-body autopsies may be crucial to understand coronavirus disease 2019 (COVID-19) pathophysiology. We aimed to analyze pathological findings in a large series of full-body autopsies, with a special focus on superinfections. Methods: This was a prospective multicenter study that included 70 COVID-19 autopsies performed between April 2020 and February 2021. Epidemiological, clinical and pathological information was collected using a standardized case report form. Results: Median (IQR) age was 70 (range 63.75?74.25) years and 76% of cases were males. Most patients (90%,) had at least one comorbidity prior to COVID-19 diagnosis, with vascular risk factors being the most frequent. Infectious complications were developed by 65.71% of the patients during their follow-up. Mechanical ventilation was required in most patients (75.71%) and was mainly invasive. In multivariate analyses, length of hospital stay and invasive mechanical ventilation were significantly associated with infections (p?=?0.036 and p?=?0.013, respectively). Necropsy findings revealed diffuse alveolar damage in the lungs, left ventricular hypertrophy in the heart, liver steatosis and pre-infection arteriosclerosis in the heart and kidneys. Conclusion: Our study confirms the main necropsy histopathological findings attributed to COVID-19 in a large patient series, while underlining the importance of both comorbid conditions and superinfections in the pathology.

 Fuente: Frontiers in Medicine, 2023, 10, 1151843

Editorial: Frontiers Media S.A.

 Año de publicación: 2023

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.3389/fmed.2023.1151843

ISSN: 2296-858X

Url de la publicación: https://doi.org/10.3389/fmed.2023.1151843

Autores/as

CÁCERES, INMACULADA

HERMIDA ROMERO, TERESA

GUERRA MERINO, ISABEL

PORTU ZAPIRAIN, JOSEBA

PÉREZ-MIES, BELÉN

SÁNCHEZ-CONDE, MATILDE

ALONSO RIAÑO, MARINA

RUBIO, RAFAEL

FORTÉS ALEN, JOSÉ

VIDAL GONZÁLEZ, ÁNXELA

SALAS ANTÓN, CLARA

MÚÑEZ, ELENA

SÁNCHEZ SÁNCHEZ, RAFAEL

CORONA-MATA, DIANA

ALDECOA ANSORREGUI, IBAN

MIRÓ, JOSÉ M.

BELOQUI PÉREZ DE OBANOS, RAQUEL