Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. The severity of COVID-19 increases with each decade of life, a phenomenon that suggest that organismal aging contributes to the fatality of the disease. In this regard, we and others have previously shown that COVID-19 severity correlates with shorter telomeres, a molecular determinant of aging, in patient's leukocytes. Lung injury is a predominant feature of acute SARS-CoV-2 infection that can further progress to lung fibrosis in post-COVID-19 patients. Short or dysfunctional telomeres in Alveolar type II (ATII) cells are sufficient to induce pulmonary fibrosis in mouse and humans. Here, we analyze telomere length and the histopathology of lung biopsies from a cohort of alive post-COVID-19 patients and a cohort of age-matched controls with lung cancer. We found loss of ATII cellularity and shorter telomeres in ATII cells concomitant with a marked increase in fibrotic lung parenchyma remodeling in post- COVID-19 patients compared to controls. These findings reveal a link between presence of short telomeres in ATII cells and long-term lung fibrosis sequel in Post-COVID-19 patients

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Aging, 2023, 15(11), 4625-4641

Editorial: Impact Journals, LLC

 Año de publicación: 2023

Nº de páginas: 17

Tipo de publicación: Artículo de Revista

 DOI: 10.18632/aging.204755

ISSN: 1945-4589

Autores/as

MARTÍNEZ, PAULA

SÁNCHEZ-VAZQUEZ, RAÚL

SAHA, ARPITA

RODRIGUEZ-DUQUE, MARIA S.

NARANJO-GONZALO, SARA

OSORIO-CHAVEZ, JOY S.

BLASCO, MARIA A.