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Torque Teno virus load predicts opportunistic Infections after kidney transplantation but Is not associated with maintenance immunosuppression exposure

Abstract: Measuring the non-pathogenic Torque Teno Virus (TTV) load allows assessing the net immunosuppressive state after kidney transplantation (KTx). Currently, it is not known how exposure to maintenance immunosuppression affects TTV load. We hypothesized that TTV load is associated with the exposure to mycophenolic acid (MPA) and tacrolimus. We performed a prospective study including 54 consecutive KTx. Blood TTV load was measured by an in-house PCR at months 1 and 3. Together with doses and trough blood levels of tacrolimus and MPA, we calculated the coefficient of variability (CV), time in therapeutic range (TTR) and concentration/dose ratio (C/D) of tacrolimus, and the MPA-area under the curve (AUC-MPA) at the third month. TTV load at the first and third month discriminated those patients at risk of developing opportunistic infections between months 1 and 3 (AUC-ROC 0.723, 95%CI 0.559?0.905, p = 0.023) and between months 3 and 6 (AUC-ROC 0.778, 95%CI 0.599?0.957, p = 0.028), respectively, but not those at risk of acute rejection. TTV load did not relate to mean tacrolimus blood level, CV, TTR, C/D and AUC-MPA. To conclude, although TTV is a useful marker of net immunosuppressive status after KTx, it is not related to exposure to maintenance immunosuppression.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Biomedicines, 2023, 11, 1410

Editorial: MDPI AG

 Año de publicación: 2023

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/biomedicines11051410

ISSN: 2227-9059

Autores/as

CAÑAMERO, LUCÍA

BENITO-HERNÁNDEZ, ADALBERTO

GONZÁLEZ, ELENA

ESCAGEDO, CLARA

RODRÍGUEZ-VIDRIALES, MARÍA

MARIA DEL MAR GARCIA SAIZ

ROSALIA MARIA VALERO SAN CECILIO

LARA BELMAR VEGA

MARIA VICTORIA FRANCIA GIL