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Abstract: Measuring the non-pathogenic Torque Teno Virus (TTV) load allows assessing the net immunosuppressive state after kidney transplantation (KTx). Currently, it is not known how exposure to maintenance immunosuppression affects TTV load. We hypothesized that TTV load is associated with the exposure to mycophenolic acid (MPA) and tacrolimus. We performed a prospective study including 54 consecutive KTx. Blood TTV load was measured by an in-house PCR at months 1 and 3. Together with doses and trough blood levels of tacrolimus and MPA, we calculated the coefficient of variability (CV), time in therapeutic range (TTR) and concentration/dose ratio (C/D) of tacrolimus, and the MPA-area under the curve (AUC-MPA) at the third month. TTV load at the first and third month discriminated those patients at risk of developing opportunistic infections between months 1 and 3 (AUC-ROC 0.723, 95%CI 0.559?0.905, p = 0.023) and between months 3 and 6 (AUC-ROC 0.778, 95%CI 0.599?0.957, p = 0.028), respectively, but not those at risk of acute rejection. TTV load did not relate to mean tacrolimus blood level, CV, TTR, C/D and AUC-MPA. To conclude, although TTV is a useful marker of net immunosuppressive status after KTx, it is not related to exposure to maintenance immunosuppression.
Fuente: Biomedicines, 2023, 11, 1410
Editorial: MDPI AG
Año de publicación: 2023
Nº de páginas: 13
Tipo de publicación: Artículo de Revista
DOI: 10.3390/biomedicines11051410
ISSN: 2227-9059
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CAÑAMERO, LUCÍA
BENITO-HERNÁNDEZ, ADALBERTO
GONZÁLEZ, ELENA
ESCAGEDO, CLARA
RODRÍGUEZ-VIDRIALES, MARÍA
MARIA DEL MAR GARCIA SAIZ
ROSALIA MARIA VALERO SAN CECILIO
LARA BELMAR VEGA
MARIA DE LOS ANGELES DE COS COSSIO
MARIA VICTORIA FRANCIA GIL
JUAN CARLOS RUIZ SAN MILLAN
EMILIO RODRIGO CALABIA
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