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 Detalle_Publicacion

Macrophage and microglia ontogeny in the mouse visual system can be traced by the expression of Cathepsins B and D.

Abstract: Here, we show a detailed chronotopographical analysis of cathepsin B and D expression during development of the mouse visual system. Both proteases were detected in large rounded/ameboid cells usually located in close relationship with prominent sites of extensive physiological cell death. In concordance with their morphological features and topographical distribution, we demonstrate that expressing cells corresponded with macrophages and microglial precursors. We found that as microglial precursors differentiated the expression of both cathepsins was down-regulated. Of interest, cathepsin B and D transcripts were never observed in degenerating cells. Our findings point to a role for cathepsin D and B in cell debris degradation after apoptotic processes rather than promoting cell death, as proposed for other developmental models. Additionally their pattern of expression suggests a role in the maturation of the microglial precursors

 Autoría: Bejarano-Escobar R., Holguín-Arévalo M., Montero J., Francisco-Morcillo J., Martín-Partido G.,

 Fuente: Developmental Dynamics, 2011, 240, 1841-1855

Editorial: Wiley-Liss

 Año de publicación: 2011

Nº de páginas: 15

Tipo de publicación: Artículo de Revista

 DOI: 10.1002/dvdy.22673

ISSN: 1058-8388,1097-0177

Url de la publicación: https://doi.org/10.1002/dvdy.22673

Autores/as

BEJARANO-ESCOBAR, RUTH

HOLGUÍN ARÉVALO, MARÍA SALUD

FRANCISCO MORCILLO, JAVIER

MARTÍN PARTIDO, GERVASIO