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Expression and function of toll-like receptors in peripheral blood mononuclear cells of patients with polymyalgia rheumatica and giant cell arteritis

Abstract: Objective: To investigate the expression and function of the Toll-like receptor (TLR) family in peripheral blood mononuclear cells (PBMCs) of patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). Methods: The authors analysed 70 patients with PMR, 20 with GCA, and 24 healthy controls (HC). TLR expression was assessed by flow cytometry. TLR function was assessed by stimulating PBMCs with specific ligands. Results: A significantly increased expression of TLR7 in PBMCs of patients with active disease compared with HC was found. Despite increased expression of TLR7, circulating monocytes from patients showed a significantly lower in vitro response to TLR7 agonists. No amino acid substitutions predicted to be functionally damaging were found in TLR7. A normal response to specific TLR7 agonists in patients in complete remission eliminated a genetic defect. TLR expression and function were also affected to some degree in other diseases characterised by a strong acute phase response. Conclusion: These data suggest activation of TLR7 during the active phase of PMR and GCA which resolves with complete disease remission. Whether this finding is the consequence of the marked inflammatory process in these disorders or activation by natural ligands remains to be explored.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Rodríguez L.A., López-Hoyos M., Mata C., Fontalba A., Alen J.C., Marín M.J., Fernández-Luna J.L., Balbín J.A., Zaldunbide M.A., Blanco R., Martínez-Taboada V.M.,

 Fuente: Annals of the Rheumatic Diseases, 2011, 70(9), 1677-1683

Editorial: BMJ Publishing Group

 Año de publicación: 2011

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1136/ard.2010.140194

ISSN: 0003-4967,1468-2060

Autores/as

ÁLVAREZ RODRÍGUEZ, LORENA

MATA, CRISTINA

FONTALBA, FONTALBA

JAIME CALVO ALEN

MARÍN, MARÍA JOSÉ

JOSE LUIS FERNANDEZ LUNA

JESUS AGÜERO BALBIN

ARANZAMENDI ZALDUNBIDE, MAITANE