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Using structural equations to test for a direct effect of some antipsychotics on triglyceride levels in drug-naïve first-episode psychosis patients.

Abstract: Some antipsychotics probably increase the risk of metabolic syndrome. Antipsychotics may differentially influence some elements of metabolic syndrome (obesity, hyperlipidemia, hyperglycemia or hypertension) through various pharmacological mechanisms. In a published study of all first psychotic episodes in a Spanish hospital's catchment area population in Cantabria (Spain), patients were randomly assigned to receive haloperidol (3?9 mg/day), olanzapine (5?20 mg/day) or risperidone (3?6 mg/day). In this article, a structural-equation modeling approach tested the mechanistic hypothesis that olanzapine directly (without the mediation of weight gain) increases triglyceride levels, whereas risperidone and haloperidol do not have these effects. A structural equation model was built using the 110 patients whose assigned antipsychotic was not changed during the first 3 months of treatment, and who provided both triglyceride and body mass index (BMI) measurements at baseline and at the end of the 3rd month of treatment. A second structural equation included 72 patients whose antipsychotic was not changed during the first year. After 3 months and controlling for confounders, olanzapine patients had triglyceride levels that were 29.2 mg/dL higher [95% confidence interval, (10.9, 47.5)] than those of risperidone patients with comparable baseline triglyceride levels. After 12 months, they were 63.1 mg/dL higher (18.6, 107.6) than those of patients with a comparable history of triglyceride values during the first 3 months. Haloperidol effects on triglyceride levels and BMI were no different from those of risperidone. In conclusion, olanzapine increased triglyceride levels without the mediation of weight gain during a one-year study in naïve patients.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Schizophrenia Research, 2011, 131(1-3), 82-89

Editorial: Elsevier

 Fecha de publicación: 01/09/2011

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.schres.2011.06.006

ISSN: 0920-9964,1573-2509

Url de la publicación: https://doi.org/10.1016/j.schres.2011.06.006

Autoría

DÍAZ, FRANCISCO J.

ROCIO PEREZ IGLESIAS

IGNACIO MATA PASTOR

OBDULIA MARTINEZ GARCIA

JOSE LUIS VAZQUEZ BARQUERO

LEON, JOSE DE

BENEDICTO CRESPO FACORRO