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Abstract: Overall and regional cortical thinning has been observed at the first break of schizophrenia. Due to the fact that structural abnormalities in the insular cortex have been described in schizophrenia, we investigated insular thickness anomalies in first episode schizophrenia. Participants comprised 118 schizophrenia patients and 83 healthy subjects. Magnetic resonance imaging brain scans (1.5 T) were obtained, and images were analyzed by using BRAINS2. The contribution of sociodemographic, cognitive and clinical characterictics was controlled. Schizophrenia patients demonstrated a significant right insular thinning, and a significant group by gender interaction was found for left insular thickness. Post-hoc comparisons revealed that male schizophrenia patients had a significant left insular thinning compared with healthy male subjects. There were no significant associations between insular thickness, the severity of symptoms at baseline and cognitive measurements and premorbid variables. The fact that insular thinning is already present at early phases of the illness and is independent of intervening variables offers evidence for the potential of these changes to be a biological marker of the illness.
Fuente: Psychiatry Research, 2010, 182(3), 216-222
Editorial: Elsevier
Fecha de publicación: 30/06/2010
Nº de páginas: 7
Tipo de publicación: Artículo de Revista
DOI: 10.1016/j.pscychresns.2010.03.001
ISSN: 0165-1781,1872-7123
Url de la publicación: https://doi.org/10.1016/j.pscychresns.2010.03.001
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ROBERTO ROIZ SANTIAÑEZ
ROCIO PEREZ IGLESIAS
LUIS CARLOS QUINTERO URIBE
DIANA TORDESILLAS GUTIERREZ
IGNACIO MATA PASTOR
MARIA ROSA AYESA ARRIOLA
AGUSTIN GUTIERREZ GUTIERREZ
SÁNCHEZ, ELENA
JOSE LUIS VAZQUEZ BARQUERO
BENEDICTO CRESPO FACORRO
JOSÉ MANUEL RODRÍGUEZ SÁNCHEZ
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