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Abstract: The aim of the study was to identify predictors associated with a lower likelihood of achieving a clinical remission 1 year after the first break of the illness. Participants were 174 consecutive subjects included in a first episode programme with no prior treatment with antipsychotic medication. Patients were assigned to haloperidol, olanzapine or risperidone in a randomized, open-label, prospective clinical trial. The main outcome variable was the remission criteria developed by the Remission in Schizophrenia Working Group. Clinical variables were included in a logistic regression analysis in order to predict the remission state at 1 year. At 1 year, 31% of patients met criteria for remission. The logistic regression analysis revealed that the strongest predictors of achieving clinical remission 1 year away from a first episode of non-affective psychosis were the length of duration of untreated psychosis (DUP), the severity of negative symptomatology and the educational level attained at baseline. The results suggest that: (1) patients with a lengthy DUP, a greater severity of negative symptomatology at baseline and with a lower education level are in a higher risk of not achieving a clinical remission during the first year of treatment; and (2) early intervention clinical programs should aim to reduce the length of DUP in order to provide a better outcome for patients.
Fuente: Psychiatry Research, 2013, 206(2-3), 181-187
Editorial: Elsevier
Año de publicación: 2013
Nº de páginas: 7
Tipo de publicación: Artículo de Revista
DOI: 10.1016/j.psychres.2012.10.011
ISSN: 0165-1781,1872-7123
Url de la publicación: https://doi.org/10.1016/j.psychres.2012.10.011
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DÍAZ, IGNACIO
JOSE MARIA PELAYO TERAN
ROCIO PEREZ IGLESIAS
IGNACIO MATA PASTOR
TABARES SEISDEDOS, RAFAEL
PAULA SUAREZ PINILLA
JOSE LUIS VAZQUEZ BARQUERO
BENEDICTO CRESPO FACORRO
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