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Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis

Abstract: Genetic factors play an important role in the understanding of clinical response to antipsychotic treatments. We aimed to assess the effect of the catechol-O-methyltransferase (COMT) genotype in the short-term (6 weeks) clinical response of 161 first-episode psychosis patients. COMT genotype was not related to clinical response at 6 weeks. Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response.

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Autoría: Pelayo-Terán J.M., Pérez-Iglesias R., Vázquez-Bourgon J., Mata I., Carrasco-Marín E., Vázquez-Barquero J.L., Crespo-Facorro B.,

Fuente: Psychiatry Research, 2011, 185(1-2), 286-289

Editorial: Elsevier

Fecha de publicación: 30/01/2011

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

DOI: 10.1016/j.psychres.2010.06.006

ISSN: 0165-1781,1872-7123

Url de la publicación: https://doi.org/10.1016/j.psychres.2010.06.006

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Autoría

JOSE MARIA PELAYO TERAN

ROCIO PEREZ IGLESIAS

JAVIER VAZQUEZ BOURGON

IGNACIO MATA PASTOR

EUGENIO CARRASCO MARÍN

JOSE LUIS VAZQUEZ BARQUERO

BENEDICTO CRESPO FACORRO

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