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 Detalle_Publicacion

No association between migraine frequency, white matter lesions and silent brain infarctions: a study in a series of women with chronic migraine

Abstract: Background and purpose: It has been suggested that silent infarctions (SIs) and hyperintense white matter lesions (WMLs) are related to migraine frequency. We studied their prevalence and anatomical distribution in patients with chronic migraine (CM). Methods: A total of 96 women with CM [mean age 43 (range 16-65) years] and 29 women with episodic migraine (EM) [mean age 36 (range 16-58) years] underwent 1.5-T magnetic resonance imaging following the CAMERA protocol. The number, size and location of SIs and deep WMLs were recorded and a modified Fazekas scale was applied to assess periventricular WMLs. Results: White matter lesions were found in 59 (61.5%) women with CM and 17 (58.6%) women with EM (odds ratio, 1.13; 95% confidence intervals, 0.48-2.62; P = 0.784). The majority (63% CM and 71% EM) were small deep WMLs. Exclusive periventricular WMLs were exceptional. Of the 739 WMLs seen in patients with CM, 734 (99.3%) were hemispheric and mostly frontal (81%). Posterior fossa WMLs were seen in only five (5.2%) women with CM (always in the pons) and two (6.9%) women with EM. Age >45 years was the only vascular risk factor associated with a higher WML number (median: 0 < 45 years and 3 > 45 years; P = 0.004). We found seven SIs in six women with CM (6.3%). Conclusions: As compared with the expected prevalence at this age, this study confirms that the prevalence of WMLs, in most cases small, deep and frontal, was increased in CM and EM. However, our results do not support an association of WMLs or SIs with a higher frequency of attacks, but with the presence of vascular risk factors and mainly age >45 years.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Eur J Neurol . 2020 Aug;27(8):1689-1696.

Editorial: Wiley

 Fecha de publicación: 01/08/2020

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/ene.14284

ISSN: 1351-5101,1468-1331

Url de la publicación: https://www.doi.org/10.1111/ene.14284

Autoría

MEILÁN, A.

LARROSA, D.

RAMÓN, C.

CERNUDA-MOROLLÓN, E.

MARTÍNEZ-CAMBLOR, P.

SAIZ, A.

SANTAMARTA, E.

PÉREZ-PEREDA, S.