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Ten-year course of cognition in first-episode non-affective psychosis patients: PAFIP cohort

Abstract: Background: A large body of research states that cognitive impairment in schizophrenia is static. Nevertheless, most previous studies lack a control group or have small study samples or short follow-up periods. Method: We aimed to address these limitations by studying a large epidemiological cohort of patients with first-episode schizophrenia spectrum disorders and a comparable control sample for a 10-year period. Results: Our results support the generalized stability of cognitive functions in schizophrenia spectrum disorders considering the entire group. However, the existence of a subgroup of patients characterized by deteriorating cognition and worse long-term clinical outcomes must be noted. Nevertheless, it was not possible to identify concomitant factors or predictors of deterioration (all Ps > 0.05). Conclusions: Cognitive functions in schizophrenia spectrum disorder are stable; however, a subgroup of subjects that deteriorate can be characterized.

 Fuente: Psychological Medicine , First View , pp. 1 - 10

Editorial: Cambridge University Press

 Fecha de publicación: 20/07/2020

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1017/S0033291720002408

ISSN: 0033-2917,1469-8978

Url de la publicación: https://www.cambridge.org/core/journals/psychological-medicine/article/abs/tenyear-course-of-cognition-in-firstepisode-nonaffective-psychosis-patients-pafip-cohort/F4AC0BD26D78173B74F6C14629974054

Autores/as

RODRÍGUEZ SÁNCHEZ, JOSÉ MANUEL

SETIÉN SUERO, ESTHER

MAYORAL VAN SON, JAQUELINE

GIL LÓPEZ, PATXI

AYESA ARRIOLA, ROSA