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Clinical and biological significance of de novo CD5+ diffuse large B-cell lymphoma in Western countries

Abstract: CD5 is a pan-T-cell surface marker and is rarely expressed in diffuse large B-cell lymphoma (DLBCL). Large-scale studies of de novo CD5+ DLBCL are lacking in Western countries. In this study by the DLBCL Rituximab-CHOP Consortium, CD5 was expressed in 5.5% of 879 DLBCL patients from Western countries. CD5+ DLBCL was associated with higher frequencies of >1 ECOG performance status, bone marrow involvement, central nervous system relapse, activated B-cell–like subtype, Bcl-2 overexpression, and STAT3 and NF-?B activation, whereas rarely expressed single-stranded DNA-binding protein 2 (SSBP2), CD30 or had MYC mutations. With standard R-CHOP chemotherapy, CD5+ DLBCL patients had significantly worse overall survival (median, 25.3 months vs. not reached, P< .0001) and progression- free survival (median, 21.3 vs. 85.8 months, P< .0001) than CD5– DLBCL patients, which was independent of Bcl-2, STAT3, NF-?B and the International Prognostic Index. Interestingly, SSBP2 expression abolished the prognostic significance of CD5 expression, suggesting a tumor-suppressor role of SSBP2 for CD5 signaling. Gene- expression profiling demonstrated that B-cell receptor signaling dysfunction and microenvironment alterations are the important mechanisms underlying the clinical impact of CD5 expression. This study shows the distinctive clinical and biological features of CD5+ DLBCL patients in Western countries and underscores important pathways with therapeutic implications.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Oncotarget, 2015, Vol. 6, No.8, pages 5615-5633

Editorial: Impact Journals

 Año de publicación: 2015

Nº de páginas: 19

Tipo de publicación: Artículo de Revista

 DOI: 10.18632/oncotarget.3479

ISSN: 1949-2553

Autores/as

XU-MONETTE, ZIJUN Y.

TU, MEIFENG

JABBAR, KAUSAR J.

CAO, XIN

TZANKOV, ALEXANDAR

VISCO, CARLO

CAI, QINGQING

SANTIAGO MONTES MORENO

AN, YUJI

DYBKAER, KAREN

CHIU, APRIL

ORAZI, ATTILIO

ZU, YOULI

BHAGAT, GOVIND

RICHARDS, KRISTY L.

HSI, ERIC D.

CHOI, WILLIAM W.L.

KRIEKEN, J. HAN VAN

MIGUEL ANGEL PIRIS PINILLA

HUH, JOORYUNG