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Abstract: Abnormal expression of the chemokine receptor CXCR4 plays an essential role in tumor cell dissemination and disease progression.However, the significance of CXCR4 overexpressionin de nava diffuse large B cell lymphoma (DLBCL) is unknown. n 743 patfents with de novo diffuse large B celllymphoma (DLBCL) who recelved standard Rltuxlmab-CHOPimmunochemotherapy,we assessed the expression of CXCR4 and dlSHCted its prognostic signiftcenceIn various DLBCL subsets. Our results showed that CXCR4+ patients was associated wlth mala,bulky tumor,high Ki-67indax,actlvatfld B-cell-like (ABC) subtype,and Myc,Bcl-2 or p53 overexpression.Moreover, CXCR4+ was an independent factor predictlng poorer progression-free survival n germinal center B-cell-like (GCB)-DLBCL,but not In ABC-DLBCL; and in patients wlth an IPI of S2,but not in those with an IPl>2. The lack of prognostic signiflcance of CXCR4 In ABC-DLBCL was likely due to the actlvatlon of p53 tumor suppressor attenuatlng CXCR4 signaling. Furthermore,concurrent CXCR4+ and BCL2 translocatlon showed dlsmal outcomes resembling but lndependent of MYC/ BCL2 double-hlt DLBCL.Gene expression profiling suggested that alteratlons in the tumor microenvlronment and lmmune responses,increased tumor prollferation and survival,and the dlsseminatlon of CXCR4+ tumor cells to distant organs or tissues were underlying molecular mechanisms responsible for the CXCR4+ associated poor prognosis.
Fuente: Oncotarget, 20 March 2015, Vol. 6, Nº 8, pages 5597-5614
Editorial: Impact Journals
Fecha de publicación: 20/03/2015
Nº de páginas: 18
Tipo de publicación: Artículo de Revista
DOI: 10.18632/oncotarget.3343
ISSN: 1949-2553
Consultar en UCrea Leer publicación
CHEN, JIAYU
XU-MONETTE, ZIJUN Y.
DENG, LIJUAN
SHEN, QI
MANYAM, GANIRAJU C.
MARTÍNEZ-LÓPEZ, AZAHARA
ZHANG, LI
SANTIAGO MONTES MORENO
VISCO, CARLO
TZANKOV, ALEXANDAR
YIN, LIHUI
DYBKAER, KAREN
CHIU, APRIL
ORAZI, ATTILIO
ZU, YOULI
BHAGAT, GOVIND
RICHARDS, KRISTY L.
HSI, ERIC D.
MIGUEL ANGEL PIRIS PINILLA
CHOI, WILLIAM W.L.
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