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 Detalle_Publicacion

MicroRNA deregulation in blood serum identifies multiple system atrophy altered pathways

Abstract: Background and Objectives MicroRNA (miRNA) changes are observed in PD but remain poorly explored in other ?-synucleinopathies such as MSA. Methods By genome-wide analysis we profiled microRNA expression in serum from 20 MSA cases compared to 40 controls. By qPCR we validated top differentially expressed microRNAs in another sample of 20 MSA and 20 controls. We also assessed the expression of MSA differentially expressed microRNAs in two consecutive sets of 19 and 18 PD patients. Results In the discovery set we identified 25 differentially expressed microRNAs associated with MSA, which are related to prion disease, fatty acid metabolism, and Notch signaling. Among these, we selected nine differentially expressed microRNAs and by qPCR confirmed array findings in a second MSA sample. MicroRNA-7641 and microRNA-191 consistently differentiated between MSA and PD. Conclusions Serum microRNA changes occur in MSA and may reflect disease-associated mechanisms. We identified two microRNAs which may differentiate MSA from PD. © 2020 International Parkinson and Movement Disorder Society

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Movement Disorders, 2020, Volume35, Issue10, 1873-1879

Editorial: John Wiley and Sons Inc.

 Fecha de publicación: 01/10/2020

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1002/mds.28143

ISSN: 0885-3185,1531-8257

 Proyecto español: MDM-2017-0729

Url de la publicación: https://doi.org/10.1002/mds.28143

Autoría

PÉREZ-SORIANO, ALEXANDRA

BRAVO, PALOMA

SOTO, MARTA

FERNÁNDEZ, MANEL

VALLDEORIOLA, FRANCESC

MUÑOZ, ESTEBAN

COMPTA, YAROSLAU

TOLOSA, EDUARD

GARRIDO, ALICIA

EZQUERRA, MARIO

FERNÁNDEZ-SANTIAGO, RUBÉN

MARTÍ, MARÍA-JOSÉ