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Genetic variability related to serum uric acid concentration and risk of Parkinson's disease

Abstract: Background: Low serum uric acid (UA) levels have been associated with increased Parkinson's disease (PD) risk and accelerated disease progression. We analyzed the effect of polymorphisms in 9 genes influencing serum UA concentration on the risk of PD. Methods: We genotyped SLC2A9 rs734553, ABCG2 rs2231142, SLC17A1 rs1183201, SLC22A11 rs17300741, SLC22A12 rs505802, GCKR rs780094, PDZK1 rs12129861, LRRC16A+SCGN rs742132, and SLC16A9 rs12356193 in 1061 PD patients and 754 controls. For each subject we calculated a cumulative genetic risk score (GRS), defined as the total number of PD-risk alleles (range, 2?15) associated to lower serum UA levels. Serum UA levels were measured in a subgroup of 365 PD cases and 132 controls. Results: Serum UA levels were significantly lower in men with PD than in controls. Subjects (both men and women) carrying more than 9 risk alleles (third GRS tertile) had a 1.5 higher risk of developing PD than subjects with less than 8 risk alleles (first GRS tertile). An inverse correlation was observed between higher GRS and lower serum UA concentration in both men and women. Conclusions: Genetic variability influencing serum UA levels might modify susceptibility to PD. © 2013 International Parkinson and Movement Disorder Society

 Fuente: Movement Disorders, 2013, 28(12), 1737-1740

 Editorial: John Wiley and Sons Inc.

 Fecha de publicación: 01/10/2013

 Nº de páginas: 4

 Tipo de publicación: Artículo de Revista

 DOI: 10.1002/mds.25507

 ISSN: 0885-3185,1531-8257

 Proyecto español: SAF2007-60700

 Url de la publicación: https://doi.org/10.1002/mds.25507

Autoría

ISABEL GONZALEZ ARAMBURU

PASCUAL SANCHEZ JUAN

JESÚS, SILVIA

GOROSTIDI, ANA

FERNÁNDEZ-JUAN, EDUARDO

CARRILLO, FÁTIMA

MARIA SIERRA PEÑA

GÓMEZ-GARRE, PILAR

CÁCERES-REDONDO, MARÍA T.

RUIZ-MARTÍNEZ, JAVIER

ONOFRE COMBARROS PASCUAL

MIR, PABLO