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Self-rated health status in spinocerebellar ataxia-results from a European multicenter study

Abstract: Patient-based measures of subjective health status are increasingly used as outcome measures in interventional trials. We aimed to determine the variability and predictors of subjective health ratings in a possible target group for future interventions: the spinocerebellar ataxias (SCAs). A consecutive sample of 526 patients with otherwise unexplained progressive ataxia and genetic diagnoses of SCA1 (117), SCA2 (163), SCA3 (139), and SCA6 (107) were enrolled at 18 European referral centers. Subjective health status was assessed with a generic measure of health related quality of life, the EQ-5D (Euroqol) questionnaire. In addition, we performed a neurological examination and a screening questionnaire for affective disorders (patient health questionnaire). Patient-reported health status was compromised in patients of all genotypes (EQ-5D visual analogue scale (EQ-VAS) mean 61.45 +/- 20.8). Specifically, problems were reported in the dimensions of mobility (86.9% of patients), usual activities (68%), pain/discomfort (49.4%), depression/anxiety (46.4%), and self care (38.2%). Multivariate analysis revealed three independent predictors of subjective health status: ataxia severity, extent of noncerebellar involvement, and the presence of depressive syndrome. This model explained 30.5% of EQ-VAS variance in the whole sample and might be extrapolated to other SCA genotypes.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Movement Disorders, 2010, 25(5), 587-595

Editorial: John Wiley and Sons Inc.

 Fecha de publicación: 01/04/2010

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1002/mds.22740

ISSN: 0885-3185,1531-8257

Url de la publicación: https://doi.org/10.1002/mds.22740spain

Autoría

SCHMITZ-HÜBSCH, TANJA

COUDERT, MATHIEU

GIUNTI, PAOLA

GLOBAS, CHRISTOPH

BALIKO, LASZLO

FANCELLU, ROBERTO

MARIOTTI, CATERINA

FILLA, ALESSANDRO

RAKOWICZ, MARYLA

CHARLES, PERRINE

RIBAI, PASCALE

SZYMANSKI, SANDRA

VAN DE WARRENBURG, BART P.C.

DÜRR, ALEXANDRA

TIMMANN, DAGMAR

BOESCH, SYLVIA

ROLA, RAFAL

DEPONDT, CHANTAL

SCHÖLS, LUDGER