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Abstract: Objectives The potential relationship between diffuse idiopathic skeletal hyperostosis (DISH) and bone microstructure has not been studied in women. We aimed to assess the association between the trabecular bone score (TBS) and DISH in postmenopausal women, as well as the role of other parameters related to bone metabolism, such as bone mineral density (BMD), calciotropic hormones, and bone remodeling markers. Methods Cross-sectional study, nested in a prospective population-based cohort (Camargo cohort). Clinical covariates, DISH, TBS, vitamin D, parathormone, BMD and serum bone turnover markers, were analyzed. Results We have included 1545 postmenopausal women (mean age, 62±9 years). Those with DISH (n = 152; 8.2%) were older and had a significantly higher prevalence of obesity, metabolic syndrome, hypertension, and type 2 diabetes mellitus (p<0.05). Moreover, they had lower TBS values (p = 0.0001) despite having a higher lumbar spine BMD (p<0.0001) and a higher prevalence of vertebral fractures than women without DISH (28.6% vs. 15.1%; p = 0.002). When analyzing DISH through Schlapbach grades, women without DISH had a median TBS value consistent with a normal trabecular structure while the values for women with DISH from grades 1 to 3 were consistent with a partially degraded trabecular structure. Women with vertebral fractures and DISH had a mean TBS corresponding to a degraded trabecular structure (1.219±0.1). After adjusting for confounders, the estimated TBS means were 1.272 (1.253?1.290) in the DISH group, and 1.334 (1.328?1.339) in the NDISH group (p<0.0001). Conclusion An association between DISH and TBS has been shown in postmenopausal women, in which hyperostosis has been significantly and consistently related to trabecular degradation and, therefore, to deterioration in bone quality after adjusting for confounding variables
Fuente: Seminars in Arthritis and Rheumatism, 2023, 61, 152217
Editorial: Elsevier
Año de publicación: 2023
Nº de páginas: 8
Tipo de publicación: Artículo de Revista
DOI: 10.1016/j.semarthrit.2023.152217
ISSN: 0049-0172,1532-866X
Proyecto español: PI21/00532
Url de la publicación: https://doi.org/10.1016/j.semarthrit.2023.152217
Consultar en UCrea Leer publicación
STEFANIE F. PINI
PARIENTE, EMILIO
JOSE MANUEL OLMOS MARTINEZ
MARTA MARTIN MILLAN
PASCUA, RAQUEL
VICTOR MANUEL MARTINEZ TABOADA
JOSE LUIS HERNANDEZ HERNANDEZ
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