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Analysis of the rs20541 (R130Q) polymorphism in the IL-13 gene in patients with elderly-associated chronic inflammatory diseases

Abstract: Objective: To investigate whether there is association between the rs20541 (R130Q) polymorphism in the IL-13 gene with disease susceptibility and clinical subsets in patients with elderly-associated inflammatory chronic diseases. Material and methods: Seventy-eight patients with giant cell arteritis (GCA), 174 with polymyalgia rheumatica (PMR), 90 elderly-onset rheumatoid arthritis (EORA), and 465 healthy controls from the same geographic area were studied. The rs20541 (R130Q) polymorphism in the IL-13 gene was evaluated by PCR-RFLP. Circulating levels of IL-13 were measured by ELISA. Results: A higher frequency of the AA genotype [2.349 (0.994?5.554)], as well as the allele A [1.589 (1.085?2.328] and the A carriers [1.656 (1.021?2.686)] (P<.05) was observed in the GCA patients. No significant differences were observed in the PMR and EORA patients as compared with the healthy controls. Neither difference was observed among the different disease groups studied. In GCA patients, differences in the genotype were associated with a worse prognosis. In PMR patients,the AA genotype was associated with higher levels of serum IL-13 than the GA one. However, such an association was not detected for controls and the other disease groups. Conclusions: GCA is more frequent in carriers of the rs20541 (R130Q) polymorphism in the IL-13 gene. The utility of this polymorphism to predict the GCA prognosis must be confirmed in studies with a higher number of patients.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Lorena Álvarez Rodríguez; Marcos López Hoyos; Eugenio Carrasco Marín; Cristina Mata; Jaime Calvo Alén; Elena Aurrecoechea Aguinaga; Ricardo Blanco; Teresa Ruiz; Pedro Muñoz Cacho; Ignacio Villa; Víctor Manuel Martínez Taboada

 Fuente: Reumatología Clínica, 2012, 8(6), 321-327

Editorial: Elsevier España

 Año de publicación: 2012

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.reuma.2012.04.006

ISSN: 1699-258X,1885-1398,1886-3604

Url de la publicación: https://doi.org/10.1016/j.reuma.2012.04.006