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MARIA JESUS LUCAS GAY

Publications
16
Projects
9
Thesis
2

Licenciada en Bioquímica por la Universidad del País Vasco y Doctora en Biología Molecular por la Universidad de Cantabria. Realizó una estancia posdoctoral de tres años en el Gene Center de la Universidad LMU de Múnich y de siete años en el CIC bioGUNE. En 2018, se incorporó a la Universidad de Cantabria con un contrato Ramón y Cajal, y desde 2023 es Profesora PCD-I3 del área de Genética del Departamento de Biología Molecular.

maria.lucas@unican.es

Edificio IBBTEC. c/ Albert Einstein, 22 (PCTCAN). 39011 Santander

Profesor Contratado Doctor (I3)

Doctor por la Universidad de Cantabria

Ingeniería De Proteínas

INST. DE BIOMEDICINA Y BIOTECNOLOGÍA DE CANTABRIA

Specialty areas: GENETICA

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Publications Projects Supervised Theses

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16 results

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3

Article

Nature Chemistry, 2026, 18, 585-596

Authorship: ELISABETH HENNES, BELÉN LUCAS, NATALIE S. SCHOLES, XIU-FEN CHENG, DANIEL C. SCOTT, MATTHIAS BISCHOFF, KATHARINA REICH, RAPHAEL GASPER, MARIA JESUS LUCAS GAY, TENG TENG XU, SOFIA ROSSINI, LISA-MARIE PULVERMACHER, LARA DÖTSCH, HANA IMRICHOVA, ALEXANDRA BRAUSE, SISKA FÜHRER, REDDY NAREDLA KESAVA, SONJA SIEVERS, KAMAL KUMAR, PETRA JANNING

07/01/2026

Prokaryotic PfaB is a terrminal acyltransferase that determines the final PUFA product

Article

Protein Science, 2026, 35(3), e70497

Authorship: NAHUEL ISMAEL LOFEUDO ALVAREZ, AURORA MARTIN GONZALEZ, MATEO JACOME GONZALEZ, XIA WAN, MARIA JESUS LUCAS GAY, GABRIEL MONCALIAN MONTES

2026

Design, synthesis, and structural evolution of pseudo-natural product IDO1 inhibitors and degraders

Article

Angewandte Chemie International Edition, 2025, e18753

Authorship: XIU-FEN CHENG, BELÉN LUCAS, PHILIPP LÁMPARA, STEFANO UGEL, SUYUAN CHEN, ANKE UNGER, MATÍAS BISCHOFF, SOHEILA REZAEI ADARIANI, KESAVA REDDY NAREDLA, KAMAL KUMAR, ANNIKA SCHMIDT, CARSTEN STROHMANN, PETRA JANNING, RAFAEL GASPER, MARIA JESUS LUCAS GAY, MARÍA LUCAS, MALTE GERSCH, SONJA SIEVERS, VINCENZO BRONTË, SLAVA ZIEGLER

2025

Selective cargo and membrane recognition by SNX17 regulates its interaction with Retriever

Article

EMBO Reports, 2025, 26, 470-493

Authorship: AURORA MARTIN GONZALEZ, IVÁN MÉNDEZ GUZMÁN, MAIALEN ZABALA-ZEARRETA, ANDREA QUINTANILLA CAVIA, ARTURO GARCÍA LÓPEZ, EVA MARTINEZ LOMBARDIA, DAVID ALBESA-JOVÉ, JUAN CARLOS ACOSTA COBACHO, MARIA JESUS LUCAS GAY

2024

TOR complex 1 negatively regulates NDR kinase Cbk1 to control cell separation in budding yeast

Article

PLoS biology, 2023, 21(8), e3002263

Authorship: MAGDALENA MARIA FOLTMAN, IVÁN MÉNDEZ GUZMÁN, JOAN J. BECH-SERRA, CAROLINA DE LA TORRE, JENNIFER L. BRACE, ERIC L. WEISS, MARIA JESUS LUCAS GAY, ETHEL QUERALT, ALBERTO SANCHEZ DIAZ

2023

CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion

Article

J Cell Biol. 2020 Sep 7;219(9):e201912159

Authorship: AARON J. FARRUGIA, JAVIER RODRIGUEZ MARTINEZ, JOSE L. ORGAZ, MARIA JESUS LUCAS GAY, VICTORIA SANZ MORENO, FERNANDO CALVO GONZALEZ

2020

Structural insight into the membrane targeting domain of the Legionella deAMPylase SidD

Article

PLoS Pathog. 2020 Aug; 16(8): e1008734

Authorship: IGOR TASCÓN, XIAO LI, MARIA JESUS LUCAS GAY, D'ANNA DELSON, ANDER VIDAURRAZAGA, YI-HAN LIN, ADRIANA L. ROJAS, AITOR HIERRO, MATTHIAS P MACHNER

2020

Structural insights into Pseudomonas aeruginosa Type six secretion system exported effector 8

Article

Journal of Structural Biology.Volume 212, Issue 3, 1 December 2020, 107651

Authorship: AMAIA GONZÁLEZ MAGAÑA, MARÍA ANGELA SAÍNZ POLO, GABRIELA PRETRE, RETINA ÇAPUNI, MARIA JESUS LUCAS GAY, JON ALTUNA, ITXASO MONTANCHEZ, PAOLA FUCINI, DAVID ALBESA JOVÉ

2020

Identification of relaxase-DNA covalent complexes and DNA strand transfer reaction products by polyacrylamide gel electrophoresis

Book part

Horizontal gene transfer: methods and protocols

Authorship: MARIA JESUS LUCAS GAY, GABRIEL MONCALIAN MONTES

2020

Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: role of the Acidic Subdomain

Article

J Mol Biol. 2019 Jan 18; 431(2):444-461

Authorship: YOVANA CABRERA, LEIRE DUBLANG, JOSÉ ANGEL FERNÁNDEZ-HIGUERO, DAVID ALBESA-JOVÉ, MARIA JESUS LUCAS GAY, ANA ROSA VIGUERA, MARCELO E. GUERIN, JOSE M.G. VILAR, ARTURO MUGA, FERNANDO MORO

2019

RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases

Article

PLoS Pathog. 2018 Feb 7;14(2):e1006897.

Authorship: YI-HAN LIN, MARIA JESUS LUCAS GAY, TIMOTHY R. EVANS, GUILLERMO ABASCAL-PALACIOS, ALEXANDRA G. DOMS, NICOLE A. BEAUCHENE, ADRIANA L. ROJAS, AITOR HIERRO, MATTHIAS P. MACHNER

2018

Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL

Article

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11151-E11160.

Authorship: MIGUEL ROMANO-MORENO, ADRIANA L. ROJAS, CHAD D. WILLIAMSON, DAVID C. GERSHLICK, MARIA JESUS LUCAS GAY, MICHAIL N. ISUPOV, JUAN S. BONIFACINO, MATTHIAS P. MACHNER, AITOR HIERRO

2017

Endosomal trafficking: retromer and retriever are relatives in recycling

Article

Current Biology, 2017, 27(22), R1233-R1236

Authorship: DAVID C. GERSHLICK, MARIA JESUS LUCAS GAY

2017

Retromer

Article

Curr Biol. 2017 Jul 24; 27(14):687-689

Authorship: MARIA JESUS LUCAS GAY, AITOR HIERRO

2017

Structural mechanism for cargo recognition by the retromer complex

Article

Cell, 2016, 167(6), 1623-1635

Authorship: MARIA JESUS LUCAS GAY, DAVID C. GERSHLICK, ANDER VIDAURRAZAGA, ADRIANA L. ROJAS, JUAN S. BONIFACINO, AITOR HIERRO

2016

Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5

Article

PNAS. 2014, Aug 26; 111(34):E3514-23

Authorship: MARIA JESUS LUCAS GAY, ANDREW H. GASPAR, CHIARA PALLARA, ADRIANA LUCELY ROJAS, JUAN FERNÁNDEZ-RECIO, MATTHIAS P. MACHNER, AITOR HIERRO

2014

16 results

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MARIA JESUS LUCAS GAY

Identifiers

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3

Prokaryotic PfaB is a terrminal acyltransferase that determines the final PUFA product

Design, synthesis, and structural evolution of pseudo-natural product IDO1 inhibitors and degraders

Selective cargo and membrane recognition by SNX17 regulates its interaction with Retriever

TOR complex 1 negatively regulates NDR kinase Cbk1 to control cell separation in budding yeast

CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion

Structural insight into the membrane targeting domain of the Legionella deAMPylase SidD

Structural insights into Pseudomonas aeruginosa Type six secretion system exported effector 8

Identification of relaxase-DNA covalent complexes and DNA strand transfer reaction products by polyacrylamide gel electrophoresis

Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: role of the Acidic Subdomain

RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases

Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL

Endosomal trafficking: retromer and retriever are relatives in recycling

Retromer

Structural mechanism for cargo recognition by the retromer complex

Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5