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Impact of radical nephrectomy on kidney function and prognostic factors for adverse cardiovascular events

Abstract: Introduction and objectives: To analyze the evolution of kidney function after radical nephrectomy and to evaluate risk factors for adverse cardiovascular events during a long follow-up. Material and methods: Retrospective study of patients submitted to radical nephrectomy due to renal cancer from January of 1996 to January of 2016. We evaluated their renal function after nephrectomy and during follow-up. We analyzed the possible predictive factors for adverse cardiovascular events with univariate and multivariate logistic regression analyses. Results: There was an acute drop in glomerular filtration rate (GFR) after nephrectomy (21.2ml/min), which stabilized during follow-up in most cases. We evaluated the possible predictive factors for adverse cardiovascular events with logistic regression analyses, which presented previous cardiovascular disease (0,270, 95% CI 0,123-0,594, P<.001), diabetes (0,364, 95% CI 0,162-0,818 P=.015) and de novo hypertension (0,239, 95% CI 0,098-0,581, P=.002) as independently associated with the occurrence of adverse cardiovascular events. Conclusion: There was a deleterious effect in renal function after nephrectomy which remained stable during subsequent years in most patients. Approximately half of our patients had a GFR lower than 60mL/min after nephrectomy. Previous cardiovascular disease, diabetes and de novo hypertension were shown as risk factors for adverse cardiovascular events.

 Fuente: Actas Urológicas Españolas, 2020, 44(4), 239-244

 Editorial: Elsevier-Doyma

 Año de publicación: 2020

 Nº de páginas: 6

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.acuro.2020.02.003

 ISSN: 2173-5786,0210-4806

 Url de la publicación: https://www.doi.org/10.1016/j.acuro.2020.02.003