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Metabolic syndrome and related factors in a large sample of antipsychotic naïve patients with first-episode psychosis: 3 years follow-up results from the PAFIP cohort

Abstract: Background: Latest studies in patients with first episode psychosis (FEP) have shown alter-ations in cardiovascular, immune and endocrinological systems. These findings could indicatea systemic onset alteration in the metabolic disease as opposed to justifying these findingsexclusively by antipsychotics' side effects and long-term lifestyle consequences. In any case,this population is considered at higher risk for developing cardiometabolic disorders than theirage-matched peers.Methods: This is a prospective longitudinal study. Metabolic syndrome (MetS) prevalencebetween 244 subjects with FEP and 166 controls at 3 years was compared. Additionally, weexplored whether baseline differences in any of the MetS components according to AdultTreatment Panel III definition and prescribed antipsychotic could help to predict the MetSdevelopment at 3 years. Results: Patients with FEP present a similar baseline prevalence of MetS (6.6% vs 5.4%,p = 0.320), according to ATP-III criteria. but with a higher prevalence of metabolic alterationsthan controls before the start of antipsychotic treatment. At 3-years follow-up the MetS preva-lence had increased from 6.6% to 18.3% in the FEP group, while only from 5.4% to 8.1% in thecontrol group. The multivariate model showed that, before antipsychotic exposure, a base-line altered waist circumference WC (OR = 1.1, p = 0.011), triglycerides (OR = 1.1, p = 0.043) andhigh-density lipoprotein HDL (OR = 0.9, p = 0.008) significantly predicted the presence of MetSat 3-years. We propose a predictive model of MetS at 3 years in 244 drug-naïve FEP patients.Conclusion: We found that altered WC, HDL and triglycerides at baseline predicted the presenceof full MetS after 3-years of initiating antipsychotic treatment. Our findings support the needfor interventions to improve factors related to the physical health of FEP individuals.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Garrido-Torres N., Ruiz-Veguilla M., Olivé Mas J., Rodríguez Gangoso A., Canal-Rivero M., Juncal-Ruiz M., Gómez-Revuelta M., Ayesa-Arriola R., Crespo-Facorro B., Vázquez-Bourgon J.,

 Fuente: Revista de Psiquiatria y Salud Mental

Editorial: Ediciones Doyma, S.L.

 Año de publicación: 2022

Nº de páginas: 12

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.rpsm.2022.05.003

ISSN: 1888-9891,1989-4600

Autoría

GARRIDO-TORRESA, NATHALIA

RUIZ-VEGUILLA, MIGUEL

OLIVÉ MAS, JÚLIA

RODRÍGUEZ GANGOSO, AURORA

CANAL-RIVERO, MANUEL

JUNCAL-RUIZ, MARÍA

MARCOS GOMEZ REVUELTA

MARIA ROSA AYESA ARRIOLA

BENEDICTO CRESPO FACORRO