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The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis

Abstract: Introduction: Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described the ZC3HC1 rs11556924 polymorphism as one of the most important signals associated with coronary artery disease (CAD) in non-rheumatic Caucasian individuals. In this study we evaluated the potential association of this gene polymorphism with subclinical atherosclerosis assessed by the evaluation of carotid intima-media thickness (cIMT) in RA patients. Methods: This study included 502 RA patients from Northern Spain. The ZC3HC1 rs11556924 polymorphism was genotyped with TaqMan single-nucleotide polymorphism (SNP) genotyping assays (C__31283062_10) in a 7900HT real-time polymerase chain reaction (PCR) system. cIMT was also assessed in these patients by carotid ultrasonography (US) technology. Results: RA patients carrying the TT genotype had significantly higher cIMT values than those homozygous for the CC genotype (mean ± standard deviation (SD): 0.76 ± 0.18 mm and mean ± SD: 0.71 ± 0.16 mm respectively; P = 0.03) even after adjusting the results for sex, age at the time of US study, follow-up time and traditional CV risk factors (P = 0.04) evidencing that the effect conferred by ZC3HC1 rs11556924 polymorphism is independent of the traditional CV risk factors. Conclusion: Our results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in RA.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: López-Mejías R., Genre F., García-Bermúdez M., Corrales A., González-Juanatey C., Llorca J., Miranda-Filloy J.A., Rueda-Gotor J., Blanco R., Castañeda S., Martín J., González-Gay M.A.,

 Fuente: Arthritis Research and Therapy, 2013, 15, R152

Editorial: BioMed Central

 Año de publicación: 2013

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.1186/ar4335

ISSN: 1478-6354,1478-6362

Autoría

RAQUEL LOPEZ MEJIAS

FERNANDA GENRE

GARCÍA-BERMÚDEZ, MERCEDES

ALFONSO FERNANDO CORRALES MARTINEZ

GONZÁLEZ-JUANATEY, CARLOS

FRANCISCO JAVIER LLORCA DIAZ

MIRANDA-FILLOY, JOSÉ A.

JAVIER RUEDA GOTOR

CASTAÑEDA, SANTOS