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Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis

Abstract: Introduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc). Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes. Results: No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis. Conclusions: Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Arthritis Research & Therapy, 2012, 14(3), R154

Editorial: BioMed Central

 Año de publicación: 2012

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1186/ar3890

ISSN: 1478-6354,1478-6362

 Proyecto español: SAF2009-11110

Url de la publicación: https://doi.org/10.1186/ar3890

Autoría

TERUEL, MARÍA

SIMEÓN, CARMEN P.

BROEN, JASPER

VONK, MADELON C.

CARREIRA, PATRICIA

CAMPS, MARÍA TERESA

GARCÍA-PORTALES, ROSA

DELGADO-FRÍAS, ESMERALDA

GALLEGO, MARÍA

ESPINOSA, GERARD

BERETTA, LORENZO

AIRÓ, PAOLO

LUNARDI, CLAUDIO

RIEMEKASTEN, GABRIELA

WITTE, TORSTEN

KRIEG, THOMAS

KREUTER, ALEXANDER

DISTLER, JÖRG H. W.